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《Journal of Shaanxi Normal University(Natural Science Edition)》 2014-02
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Peparation of avermectin/hydroxypropyl-β-cyclodextrin inclusion compound

LI Yuntao;GUO Ning;SHEN Wen;College of Chemistry and Chemical Engineering;College of Life Science and Engineering,Shaanxi University of Science and Technology;  
Avermectin entrapped in HP-β-cyclodextrin was investigated.The water was selected as medium to prepare the inclusion compound.Employing single factor and orthogonal tests,the best conditions of inclusion process were determined as follows:the feeding quality ratio being 100∶3,inclusion temperature at 50 ℃,inclusion time for 8h.Under these conditions,it was determined by HPLC that the inclusion efficiency was 39.6%,and the yield was 81.1%.The inclusion compound was analysed by TG.The results show that the light stability and solubility in water of avermectin entrapped in HP-β-cyclodextrin increase significantly compared with avermectin.The long-term performance of avermectin's insecticidal and acaricidal properties are improved significantly.
【Fund】: 国家自然科学基金资助项目(21144008);; 陕西省自然科学基金资助项目(2011JM2005)
【CateGory Index】: TQ450.6
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