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《Journal of Shaanxi College of Traditional Chinese Medicine》 2009-01
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Effects of Weifuning on prevention of stomach membrane heteromorphism hyperplasia in rats and on regulation of P~(53),P~(21) expression

Zhi Jiangping Jiao Junying (Shaanxi College of Traditional Chinese Medicine,Xianyang,Shaanxi,712046)  
Objective To observe prevention effect of Weifuning in Rats with CAG and DYS and regulation of P 53,P 21 expression.Methods CAG and DYS rat models were made by UDCA and anhydrous alcohol in gastritis group.Different dosage of Weifuning were used to rat models in Weifuning group to observe effect of Weifuning and P 53,P 21 expression were tested at the same time.Incidence of CAG and DYS and P 53,P 21 expression were compared among gastritis group,Weifuning group,Colloidal Bismuth Pectin group and control group.Results Incidence of CAG in gastritis group was 100 %,and DYS 83 %.Incidence of CAG in Weifuning group(high and medium dose) was 13 %~20 %,and DYS 6.6 %~13 %.And there was significant difference between two groups(P 0.01).P 53 positive expression rate in gastritis group was 58.33 %,in Weifuning group(high and medium dose) was 20 %~26 %,and there was significant difference between two groups(P 0.01).P 21 positive expression rate in gastritis group was 50.00 %,in Weifuning group(high and medium dose) was 13 %~26 %,and there was significant difference between two groups(P 0.01).Conclusion: Weifuning group(high and medium dose) prevents excessive cell hyperplasia and canceration by interfering P 53,P 21 expression,and prevents formation of CAG and inhibits DYS,thus lowering risk of CAG and DYS developing into gastric cancer.
【Fund】: 陕西省教育厅资助课题(05JK82)
【CateGory Index】: R285.5
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