A clinical control study of Qingxin Chongji-Ⅱ in the treatment of schizophrenia

HAN Bai,SUN Hao,BAI Pei-shen,et al(Dept of Neurology,Tongji Hospital of Tongji Medical College,Huazhong Science and Technology University,Wuhan 430030,China)  

Objective To evaluate the add-on therapeutic effect of the self-dispense herb formula—Qingxin Chongji-Ⅱ combined with antipsychotropics in the treatment of schizophrenia and to observe effect of Qingxin Chongji-Ⅱ on side effects of antipsychotics.Methods All the subjects diagnosed as schizophrenia according to the CCMD-3 diagnosis standard were randomized into 4 groups:treatment group 1(Qingxin Chongji-Ⅱ combined with risperidone or olanzapine) and control group 1 with risperidone or olanzapine;treatment group 2(Qingxin Chongji-Ⅱ combined with sulpiride or clozapine) and control group 2 with sulpiride or clozapine.The treatment lasted for 8 weeks.The Positive and Negative Syndrome Scales(PANSS) were used to evaluate therapeutic effects before and after treatment for 2,4,6,8 weeks,and Treatment Emergent Side Effect Scales(TESS) were used to estimate side effects.Results The total efficacy had no significant difference between treatment groups and control groups after 8-week treatment(P0.05).The total scores,the scores of positive syndrome,general syndrome scores of PANSS between treatment groups and control groups had no significant difference before and after treatment for 8 weeks(P0.05).The negative syndrome scores of PANSS between treatment groups and control groups were significantly different after 8-week treatment(P0.05).The negative syndrome scores and the rates of side effects of antipsychotics in treatment groups were significantly lower than in control groups.Conclusion Qingxin Chongji-Ⅱ has add-on effect for antipsychotics in the treatment of schizophrenia.It could improve negative syndrome of schizophrenia and reduce side effects of antipsychotics.

【Key Words】： schizophrenia Qingxin Chongji-Ⅱ efficacy
【Fund】： 山西省教育厅科技开发基金资助项目(5799814-98048)
【CateGory Index】： R277.7

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