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《Journal of Shanxi Medical University》 2008-03
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Influence of ulinastatin on nuclear factor-κB (NF-κB) expression in rats with lipopolysaccharide-induced acute kidney injury

LI Yuan-yuan,LIU Hong,LI Fang-fang(ICU,First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China)  
Objective To investigate the relations between nuclear factor-κB(NF-κB)and the development of lipopolysaccharide(LPS)-induced acute kidney injury(AKI),and to explore the effect of ulinastatin(UTI)on AKI.Methods Thirty male Wistar rats were randomly divided into three groups:control group,LPS group and LPS+UTI group.The rats were injected with normal sodium 1 ml via caudal vein in control group,with LPS 5 mg/kg via caudal vein to establish AKI model in LPS group,with UTI 100 kU/kg after injection with LPS in LPS+UTI group.Immunohistochemistry was used to determine the concentration of NF-κB in kidney tissue in rats at 6 h after LPS-induced injury.The creatinine clearance rates(Ccr)were measured and the morphological changes of kidney were observed under light microscope and electron microscope.Results Compared with control group and LPS+UTI group,Ccr significantly decreased in LPS group(P0.01),but there was no significant difference between control group and LPS+UTI group(P0.05).The concentration of NF-κB in LPS group was significantly higher than in control group and LPS+UTI group(P0.01).The level of NF-κB in LPS+UTI group was little higher than in control group(P0.05).Pathological section and microscope section showed that the inflammation reaction of kidney in LPS+UTI group was lighter than in LPS group.Conclusion UTI may alleviate LPS-induced inflammatory reaction and damage to kidney in rats.
【CateGory Index】: R96
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