A clinical control study of Qingxinchongji-Ⅰ in treatment of schizophrenia

HAN Bai1,SUN Hao2,BAI Pei-shen2,TANG Rong-hua1,CHENG Yi-nong3(1Dept of Neurology,Tongji Hospital of Tongji Medical College of Huazhong Science and Technology University,Wuhan 430030,China;2Dept of Psychiatry,First Clinical Medical College,Shanxi Medical University;3[KG*2]Taiyuan Psychiatric Hospital)  

Objective To evaluate the add-on therapeutic effect of the self-dispense herb formula-Qingxinchongji-Ⅰcombined with antipsychotropics in treatment of schizophrenia,and to observe its effect on side effects of antipsychotropics.Methods All the subjects diagnosed as schizophrenia according to CCMD-3 diagnosis standard were randomized into 4 groups:treatment group 1(Qing-xinchongji-Ⅰ combined with risperidone or olanzapine)and control group 1 without Qingxinchongji-Ⅰ;treatment group 2(Qingxinchongji-Ⅰ combined with sulpiride or clozapine)and control group 2 without Qingxinchongji-Ⅰ.The treatment lasted for 8 weeks.PANSS and TESS were used to evaluate therapeutic effects and side effects before and after treatment for 2,4,6,8 weeks,respectively.Results Total efficacy had no significant difference between treatment groups and control groups after 8-week treatment(P0.05).The total scores,negative syndrome and general syndrome of PANSS between treatment groups and control groups had no significant difference before and after treatment for 8 weeks(P0.05).The positive syndrome scores of PANSS between treatment groups and control groups were significantly different(P0.05).The positive syndrome scores and the rates of side effects of antipsychotics in treatment groups were significantly lower than in control groups.Conclusion Qingxinchongji-Ⅰ has add-on effect for antipsychotics in treatment of schizophrenia,especially effective for the positive symptoms of schizophrenia.It can reduce the side effects of antipsychotropics and has clinical value in treatment of schizophrenia.

【Key Words】： schizophrenia Qingxinchongji-Ⅰ efficacy side effects
【Fund】： 山西省教育厅科技开发基金资助项目(5799814-98048)
【CateGory Index】： R277.7

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