Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Shanxi Medical University》 2009-06
Add to Favorite Get Latest Update

The research of quercetin on tumor suppression of conlon cancer

WANG Chong1,2,TAN Sai-nan2,3,LU Cai-ling2,YAO Nan1,2,MA Xu2(1Graduate School of Peking Union Medical College,Beijing 100730,China;2Dept of Genetics,National Research Institute for Family Planning;3Family Planning Institute of Hunan Province)  
Objective To explore the influence of quercetin on the expression of P53 and its downstream gene,Gadd45a,in colon cancer cell line RKO and esophageal cancer cell line EC109.Methods The expression of P53 in RKO cells was detected by immunocytochemistry,and the mRNA and protein expression of Gadd45a in RKO cell were detected by RT-PCR and Western blot,respectively.In addition,the protein expression of Gadd45a in EC109 cells was detected by Western blot.Results The expression of P53 was induced by quercetin in a dose-dependent way.Furthermore,the mRNA and protein expression of Gadd45a was also induced by quercetin in a dose-dependent way in RKO cells.The protein expression of Gadd45a also increased in a dose-dependent manner in EC109 cell line after administration of quercetin.Conclusion Quercetin could have a suppressive effect on the tumor by inducing the expression of P53 and Gadd45a.
【Fund】: 国家重点基础研究发展计划(973计划)基金资助项目(2007CB511905)
【CateGory Index】: R735.35
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 5 Hits
1 ZHOU Li-xiang,LUO Yi-nan~,FU Shuang-lin,GE Peng-fei,ZHUANG Han-ting(Department of Neurosurgery,First Hospital,Jilin University,Changchun 130021,China);Effect of quercetin on proliferation of rat glioma C6 cells[J];Journal of Jilin University(Medicine Edition);2006-02
2 Tang Qing,Yang Ping,Zhu Tianyi.The occupational and technological college of Liaoning traditional chinese medical university,ShenYang,110101;Influence of quercetin(Qu) on hepatocarcinogenesis induced by DEN in rats[J];Medical Journal of Liaoning;2006-01
3 Xi-Ming Zhong,Ying Wu,Yu Fan,Department of Chemotherapy,Cancer Institute,the Affiliated People’s Hospital of Jiangsu University,Zhenjiang 212002,Jiangsu Province,China;Effects of Quercetin on invasion and midkine expression of human esophageal cancer cell[J];World Chinese Journal of Digestology;2008-22
4 Zhang Jie Lü Cai Zhang Ping-an et al Department of Urology, People's Hospital of Wuhan University, Wuhan;Empirical Studies on Quercetin for Inhibition of Proliferation ofhuman Uterine Cervix Cancer HeLa cells[J];Chinese Journal of Clinical Oncology;2006-08
5 LIN Hui *, WU Kai nan, KONG Ling quan. *Department of General Surgery, The Xiangtan Center Hospital of Hunan Province, Xiangtan 411200;STUDY ON THE INHIBITORY EFFECTS OF QUERCETIN ON THE OCCURRENCE AND PROLIFERATION OF EXPERIMENTAL MAMMARY CARCINOMA[J];Chinese Journal of Bases and Clincs In General Surgery;2001-05
Chinese Journal Full-text Database 10 Hits
1 ZHU Zhan-peng1,KANG Jin-song2,KONG Xiao-xia2,LUO Yi-nan1,SUN Lian-kun2(1.Department of Neurosurgery,First Hospital,Jilin University,Changchun 130021,China; 2.Department of Pathophysiology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Effects of OHAP-1 on expression of bcl-2/bax mRNA and oxidative stress in rat C6 glioma cells[J];Journal of Jilin University(Medicine Edition);2007-04
2 QIU Ji-qing,ZHU Zhan-peng,LI Run-bo,LIU Xing-ji,YU Hong-quan,ZHAO Gang(Department of Neurosurgery,First Hospital,Jilin University,Changchun 130021,China);Expression of PTEN mRNA in human brain glioma tissue and its SSCP analysis of gene mutation[J];Journal of Jilin University(Medicine Edition);2008-03
3 Zhong Xiaogang *, Wu Kainan, He Sheng, Ma Shuangwei, Kong Lingquan. *Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China;Effects of Quercetin on the Proliferation and Apoptosis in Transplantation Tumor of Breast Cancer in Nude Mice[J];Journal of Sichuan University (Medical Sciences Edition);2003-03
4 HUANG Jing,ZHANG Wei,LI Fumin,LI DanDept.of Gynecology and Obstetrics,Renmin Hospital of Wuhan University,Wuhan 430060,China;Effect of Quercetin on the Expression of Nm23 Gene in HeLa cells[J];Medical Journal of Wuhan University;2009-05
5 LI Run-qing1,SHAN Bao-en21.Center of Clinical Laboratory,Affiliated Beijing Youan Hospital of Capital Medical University,Beijing 100069,P.R.China2.Research Center,Affiliated Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,P.R.China;Correlation between anti-tumor activity of quercetin and the inhibitive effect on Wnt/β-catenin signaling pathway[J];Chinese Journal of Cancer Prevention and Treatment;2008-21
6 Zhang Yonggang,Zhang Jie,Fan Hong,et al.Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China;Effect of Quercetin on the expression and growth of Bcl-2 in lung adenocarcinoma cancer cell line A549.[J];Sichuan Medical Journal;2007-10
7 Wang Haiyan Wang Gaofagn Lin Gan Yu HaizhongDepartment of Chemistry and Biologic Science,Xiangfan College(Xiangfan Hubei 441053,China);Effect of Chinese Herbal Medicine on the Cell Cycle of Hela Cells[J];Journal of Sichuan of Traditional Chinese Medicine;2007-08
8 Zhang Guangqin~1 Zhao Haipeng~(2,3) Wang Zhenyue~3 Cheng Jianrui~3 Tang Xianming~(3,4) (Heilongjiang Vocational College of Biology Science And Technology;Harbin 150025,China) (2.Lunan Pharmaceutical Group Corporation,Linyi,276005,China; (3.College of Pharmacy,Heilongjiang University of TCM,Harbin 150040,China) (4.Harbin Food and Drug Administration,Harbin,150016,China.);Recent Advances in the Study of Chemical Constituents and Bioactivity of Rumex L.[J];World Science and Technology-Modernization of Traditional Chinese Medicine and Materia Medica;2008-05
9 ZHU Lei, HE Li-ya (College of Medical Science,Wuhan University of Science and Technology,Wuhan 430080,China);Molecular Mechanism of Antitumor Action of Quercetin[J];Journal of Wuhan Yejin University of Science and Technology;2004-02
10 Wu Kai-nan Zhong Xiaogang Ma Shuangwei et al Department of General Surge ry,the First Affiliated Hospital of Chongqing Medical University Chongqing40 0016;Inhibitory Effect of Quercetin on Growth and Angiogenesis of Transplantati on Tumor of Breast Cancer Cell line MCF-7 in Nude Mice[J];Chinese Journal of Clinical Oncology;2003-06
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 YAO Lu yu, HONG Min , LIU Chang (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China);Effects of morphine on P53 and Bcl-2 protein levels in C6 glioma cells in rats[J];Journal of Jilin University of (Medicine Edition);2004-03
2 HAN Xue mei 1,XIONG Wen ji 2,HU Guo zhong 3 (1. Department of Neurology, China Japan Union Hospital,Jilin University,Changchun 130031,China; 2. Department of Cadre Ward, First Hospital,Jilin University,Changchun 130021,China; 3. Department of Prevention and Health Pharmacy,China Japan Union Hospital,Changchun 130021,China);Effects of Ginaton on expressions of Fas and Bcl-2 protein in rats with cerebral ischemia reperfusion injury[J];Journal of Jilin University of (Medicine Edition);2004-03
3 WEI Jin-wen,FAN Yu,ZHANG You-li,WU Ying(Affiliated Hospital of Jiangsu University,Zhenjiang 212001,P.R.China);Effects of Quercetin on telomerase activity and apoptosis in gastric cancer cells[J];Shandong Medical Journal;2007-35
4 ZHONG Lu,CHEN Fangyuan, HAN Jieying, et al. Shanghai Institute of Hematology, Renji Hospital. Shanghai Second Medical University,Shanghai 200001;Effects of quercetin on cell morphology and expression of PML mRNA and protein of NB4,HL-60 cells[J];Shanghai Medical Journal;2001-01
5 WENG Yun 1, SHE Ji 2, KANG Tie-Bang 1, XU Mei-Yi 3, LIANG Nian-Ci 1 (1. Institute of Medical Biochemistry, 2. Department of Chemistry, 3. Central Laboratory, Guangdong Medical College, Zhanjiang 524023, China);Effect of sodium quercetin monosulfate on the growth of HL-60 cells[J];CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY;2000-03
6 FAN Yu~1, ZHENG Shu~2, DING Jia-yi~2 (~1Cancer Institute, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China;~2Oncology Institute of Zhejiang University, Hangzhou 310009, China);Inhibition of telomerase activity in colon cancer LS-174T cells with liposome-mediated cripto antisense oligodeoxynucleotide[J];Chinese Journal of Pathophysiology;2006-04
7 Zhang Jizeng Liu Huafu; Liu Bin; et al(Department of pathology,General Hospital,Lanzhou Military Area,PLA Lanzhou 730050);Studies on the histological classification of proliferative disease of breast and its relation with breast carcinoma[J];CHINESE JOURNAL OF PATHOLOGY;1995-01
8 Ying-Jia Ren, Qing-Yun Zhang, Department of Immunology, The School of Oncology, Peking University; Beijing Institute for Cancer Research, Beijing 100036, China Qing-Yun Zhang, Department of Medical Laboratory, Beijing Cancer Hospital, Beijing, 100036, China;Expression of midkine and its clinical significance in esophageal squamous cell carcinoma[J];世界胃肠病学杂志(英文版);2006-13
9 Wu Xiaohua, Cai Shumo,Zhang Zhiyi,Cancer Hospital,Shanghai Medical University,Shanghai 200032;ONCOPROTEINS OF nm23H1,C erbB2,p53 AND ras GENES IN OVARIAN NEOPLASMS:SIGNIFICANCE IN PREDICTING RETROPE RITONEAL LYMPH NODE METASTASIS[J];TUMOR;1997-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved