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《Journal of Shanxi Medical University》 2009-06
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The research of quercetin on tumor suppression of conlon cancer

WANG Chong1,2,TAN Sai-nan2,3,LU Cai-ling2,YAO Nan1,2,MA Xu2(1Graduate School of Peking Union Medical College,Beijing 100730,China;2Dept of Genetics,National Research Institute for Family Planning;3Family Planning Institute of Hunan Province)  
Objective To explore the influence of quercetin on the expression of P53 and its downstream gene,Gadd45a,in colon cancer cell line RKO and esophageal cancer cell line EC109.Methods The expression of P53 in RKO cells was detected by immunocytochemistry,and the mRNA and protein expression of Gadd45a in RKO cell were detected by RT-PCR and Western blot,respectively.In addition,the protein expression of Gadd45a in EC109 cells was detected by Western blot.Results The expression of P53 was induced by quercetin in a dose-dependent way.Furthermore,the mRNA and protein expression of Gadd45a was also induced by quercetin in a dose-dependent way in RKO cells.The protein expression of Gadd45a also increased in a dose-dependent manner in EC109 cell line after administration of quercetin.Conclusion Quercetin could have a suppressive effect on the tumor by inducing the expression of P53 and Gadd45a.
【Fund】: 国家重点基础研究发展计划(973计划)基金资助项目(2007CB511905)
【CateGory Index】: R735.35
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