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《Shanxi Medical Journal》 2005-01
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Experimental study on N-acetylcysteine for endotoxin-induced liver injury

WU Hu-shan,XU Rui-ling.Shanxi Medical University,Taiyuan 030001,China  
Objective To study what the mechanism of N-acetylcysteine (NAC) is if NAC can influence the liver injury induced by liposaccharide (LPS).Methods Kunming rats,male,were randomized to liver injury group,to NAC group and control group.One hour after galactosamine/liposaccharide (Galn/LPS) was administered,the parameters of TNF-α activity,MDA and GSH were measured,and histological staining of hepatic tissue was evaluated.At the same time the expression of NF-κB p65 and IκBα was also determined.Results While altering the measured parameters of TNF-α activity,and MDA,GSH,pretreatment with NAC abrogated this injury and modulated nuclear factor-κB activity.The study showed NAC can down-regulate the NF-κB translocation.Conclusion Through the regulation of redox balance,NAC influences the NF-κB p65′s translocated nuclear import so as to inhibit TNF-α′s release,relieve the liver injury.
【CateGory Index】: R575
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【Co-references】
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