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《Shanxi Medical Journal》 2006-10
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Interfering effect of Gynostemma pentaphillia on atherosclerosis caused by high cholesterol diet in rabbits

TAN Hua-bing~*,KUANG Ying-wen.~*People′s Hospital of Yunyang Medical College,Hubei 442000,China  
Objective To research the interfering effect of Gynostemma pentaphillia(Gp) on atherosclerosis(As) due to high cholesterol diet in rabbits.Methods Forty rabbits were divided into 4 groups:group A fed high lipid+ Gp,group B given simvastain,group C fed high lipid diet,and group D fed stantard diet as the control.All the animal blood lipid was determined before and on weeks 3 and 9 after the experiment.Results Pathologic changes:The ratio of As plaques to intema showed significant difference between groups A,B and C(P0.01).ET-1 levels were up-regulated significantly before than after feeding in group A,B and C(P0.05).CRP levels after feeding were gradually elevated in groups A,B and C compared to pre-feeding(P0.01). Blood lipid(TG,TC,LDL-C) levels were gradually elevated along with feeding duration expending,and showed significant difference than those of prefeeding(P0.05,P0.01). Compared to pre-feeding,HDL-C levels were significantly higher,and TG and TC levels in group A and B were lower.Conclusion The Chinese herbal medicine Gp similar to simvastatin is of an interfering effect on As in rabbits,and it may be related to protect the endotheliocyte,inhibite the inflammation,and regulate the blood lipid metabolism.
【Fund】: 湖北省十堰市科技攻关计划基金资助项目(2005075D)
【CateGory Index】: R543.3
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【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 Geng Jie Zhang Xiaoqin(School of Mathematical Sciences,Shanxi University,Taiyuan,030006);Stability Analysis of the Assay Method of Total Saponins[J];Mathematical Theory and Applications;2010-04
2 DONG Jing~1,YIN Lian~1,ZHANG Xu~(1,2),et al (1.Nanjing University ofTCM,Nanjing 210046,China;2.Key Laboratory on Prescription of Jiangsu Province,Nanjing 210046,China);Study on Components of Effective Parts Ⅰ in Zhou's Prescription of Anti-Human Lung Cancer on A549 Cells[J];Chinese Journal of Information on Traditional Chinese Medicine;2009-11
3 TAN Wei,DAI Jian-hui,XIONG Yong,YANG Min,WANG Hong-bin(School of Chemistry and Biotechnology,Yunnan University of Nationalities,Kunming 650031,China);Extraction and Determination of Steroidal Saponins from Paris Polyphylla Smith[J];Journal of Yunnan University of Nationalities(Natural Sciences Edition);2010-02
【Co-references】
Chinese Journal Full-text Database 6 Hits
1 SHU Shimin, LU Di, ZHANG Zenghui, et al.Department of TCM with Western medicine,The First Central Hospital of Baoding, Hebei, Baoding 071000;Therapeutic effect of Fufangshuanghua decoction on CRP and WBC of coronary atherosclerotic cardiopathy[J];Hebei Journal of Traditional Chinese Medicine;2008-02
2 ZHANG Qi,ZHANG Bin-xia,JIANG Xiao-xia,SHI Bing-wei(Changzhou Municiple TCM Hospital,Changzhou,Jiangsu,213003,China);Clinical Study on Effect of Xuemaitong Granule on Cervical Artherosclerosis[J];Journal of Nanjing University of Traditional Chinese Medicine;2006-03
3 GE Lan, CHENG Xiao-yu, HU Ye-bin. Department of Medicine, First Hospital Affiliated to Anhui College of Traditional Chinese Medicine. Hefei 230031, Anhui, China;Effects of Yiqihuoxuejiedu decoction (益气活血解毒汤) on C-reactive protein,interleukin-6,tumor necrosis factor and serum lipid in experimental rabbits with atherosclerosis[J];Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care;2007-05
4 Liu Chunling, et al;The Effect of Luhuang Granule(芦黄颗粒 )on the Levels of Nitric Oxide and Endothelin-1 in Rabbits with Atherosclerosis[J];Journal of Emergency in Traditional Chinese Medicine;2005-12
5 Wu Yanxia, Meng Yunhui, Tu Jinwen, et al;The Effect of Zhenganxifeng Decoction(镇肝息风汤) on Vascular Smooth Muscle Cells Proliferation and Apoptosis Induced by AngⅡ[J];Journal of Emergency in Traditional Chinese Medicine;2006-09
6 TANG Jian-hua,WANG Wei-shu,PEI Zhi-qiang,WANG Hui-long.Department of Geriatrics,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China;Relationship between lipoprotein-associated phospholipase A2 concentration and arteriosclerosis in rabbits[J];Chinese Remedies & Clinics;2009-02
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