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《Shaanxi Medical Journal》 2007-11
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Study of CD14 gene promoter region C-260T polymorphism in the Hans in Guangxi province

Xu Qunqing Wei Yesheng Liang Liyan Scientific Laboratory Center , Youjiang Medical College for Nationalities (Baise 533000)  
Objective: To study the allele frequencies and genotype distribution of CD14 gene promoter C-260T polymorphism in the Han ethnic groups in Guangxi province,and to analyze the distributions of CD14 polymorphism were among different races. Methods: The CD14 genotypes were examined by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) methods in 208 Han populations, frequencies of allele and genotype of CD14 polymorphism compared with other ethnics. Results: The frequencies of CC, CT and TT genotypes were found to be 32.2%, 46.6% and 21.2%;the frequencies of C、T allele were found to be 55.5% and 44.5% in the Hans populations. Compared with czech populations, the CD14 polymorphism was significantly different. Conclusion: There is a CD14 gene promoter C-260T polymorphism in the Hans in Guangxi, whose distribution is significantly different in different ethnic populations. The variation of CD14 gene polymorphism among different ethnic groups might account for the varied clinical spectrum of some CD14 related diseases.
【Fund】: 广西自治区科学基金资助项目(0447060 04009);; 广西自治区教育厅课题(200420);; 右江民族医学院科研基金资助项目
【CateGory Index】: R394
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