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《Shaanxi Medical Journal》 2014-12
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Effects and mechanism on learning and memory of giant knotweed in AD model mice

Zhu Wei;Li Zhi;Zhang Dan;Luzhou Medical College;Luzhou 646000;  
Objective:To observe the influence of giant knotweed on learning and memory in AD model mice,discuss about improving learning and memory mechanisms.Methods:The mice Alzheimer's Disease model was developed by injecting Aβ1~42into lateral ventricle.By Morris water maze test,observe the effect on learning and memory ability,testtotal antioxidant capacity,the content of MDA,AChE and NO in brain.Results:In treating groups by giant knotweed,the ability of learning and memorizing were improved,total antioxidant capacity was increased,MDA was decreased and the content of Ache and NO were reduced.Conclusion:Giant knotweed has protective effects on AD mice induced by Aβ,its mechanisms are probably owning to antioxidation and inhibiting the activity of AChE and NO.
【Fund】: 四川省教育厅项目(No 2011-103)
【CateGory Index】: R285.5;R-332
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