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《Journal of Modern Oncology》 2007-12
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The clinical analysis of chemotherapy of taxol plus poldine for ovarian carcinoma

LIU Ying-lan,HAN Xu,XU Bai,ZHENG Jian-hua The Obstetric and Gynecology Department of the First Affiliate Hospital of Harbin Medical University,Harbin 150001,China  
Objective:To evaluate the therapeutic effects and toxicities of intraperitoneal and intravenous chemotherapy of taxol plus cisplatin in advanced ovarian cancer.Methods:Total of 27 cases patients of ovarian epithelial carcinoma were divided to four groups A1 group,taxol plus poldine intravenous chemotherapy(5 cases);A2 group,taxol intravenous chemotherapy and poldine intraperitoneal chemotherapy(7 cases);B1 group,paclitaxel plus poldine intraperitoneal chemotherapy(6 cases);B2 group,paclitaxel intravenous chemotherapy and poldine intraperitoneal chemotherapy(9 cases).The toxicities and the short term effects were observed after four courses of therapy.Results:Among 27 cases 25 patients completed four courses therapy,The overall effective rates,A1 group was 60%(3/5),A2 group 71.4%(5/7),B1 group 50%(3/6),B2 group 66.7%(6/9).For side effects there were significance difference among taxol groups and paclitaxel group,among sigle intravenous chemotherapy and intravenous plus intraperitoneal combination chemotherapy(P0.05).Conclusion:The chemotherapy plus paclitexal was effective for advanced ovarian cancer and the toxicities of intravenous plus intraperitoneal combination chemotherapy was lower than single intravenous chemotherapy.The heart toxicity of taxol was lower than paclitexal.
【CateGory Index】: R737.31
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