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《Journal of Modern Oncology》 2007-12
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The clinical analysis of chemotherapy of taxol plus poldine for ovarian carcinoma

LIU Ying-lan,HAN Xu,XU Bai,ZHENG Jian-hua The Obstetric and Gynecology Department of the First Affiliate Hospital of Harbin Medical University,Harbin 150001,China  
Objective:To evaluate the therapeutic effects and toxicities of intraperitoneal and intravenous chemotherapy of taxol plus cisplatin in advanced ovarian cancer.Methods:Total of 27 cases patients of ovarian epithelial carcinoma were divided to four groups A1 group,taxol plus poldine intravenous chemotherapy(5 cases);A2 group,taxol intravenous chemotherapy and poldine intraperitoneal chemotherapy(7 cases);B1 group,paclitaxel plus poldine intraperitoneal chemotherapy(6 cases);B2 group,paclitaxel intravenous chemotherapy and poldine intraperitoneal chemotherapy(9 cases).The toxicities and the short term effects were observed after four courses of therapy.Results:Among 27 cases 25 patients completed four courses therapy,The overall effective rates,A1 group was 60%(3/5),A2 group 71.4%(5/7),B1 group 50%(3/6),B2 group 66.7%(6/9).For side effects there were significance difference among taxol groups and paclitaxel group,among sigle intravenous chemotherapy and intravenous plus intraperitoneal combination chemotherapy(P0.05).Conclusion:The chemotherapy plus paclitexal was effective for advanced ovarian cancer and the toxicities of intravenous plus intraperitoneal combination chemotherapy was lower than single intravenous chemotherapy.The heart toxicity of taxol was lower than paclitexal.
【CateGory Index】: R737.31
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【References】
Chinese Journal Full-text Database 1 Hits
1 Huang Weibing,Zhu Min,Cheng Meiying(The First People's Hospital of Zhenjiang,Zhenjiang 212002,China);The Clinical Observation of Chemotherepy Combined with Intraperitoneal Chemotherepy in Advanced Ovarian Carcinoma[J];Journal of Basic and Clinical Oncology;2008-06
【Citations】
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1 PENG Zhi-lan ,QIAN Xiao -le ,ZHENG Ai,etal;Observation of the Treatment Using Taxotere Associate with Carboplatinum in Ovarian Cancer Chemotherapy[J];West China Medical Journal;2003-03
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【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 WU Tao,CUI Donghai,WANG XiaofangAnyang Tumour Hospital,Anyang 455000,China;Clinical Research of Paclitaxel plus Carboplatin and Paclitaxel plus Cisplatin for Treatment of Advanced Breast Cancer[J];Journal of Medical Forum;2006-18
2 XU Yu-xia1,ZHANG Peng-tian21Xinjiang Animal Husbandry Hospital,Fuyun 836100,China;2Department of Radiology,Shaanxi University of Chinese Medicine Affiliated Hospital,Xianyang 712000,China;Combination of docetaxel and carboplatin in the treatment of advanced non-small cell lung cancer[J];Journal of Modern Oncology;2009-03
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