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《Journal of Modern Oncology》 2015-10
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Clinical efficacy of intraperitoneal perfusion of compound matrine injection and cisplatin on malignant ascites

Jia Gang;Zhang Hongzhi;Jiang Huijuan;Department of Oncology,Henan University Huaihe Hospital;Department of Radiotherapy,Henan University Huaihe Hospital;  
Objective: To study the therapeutic efficacy of intraperitoneal perfusion of Compound Matrine injection and Cisplatin on malignant ascites. Methods: Forty- two patients of malignant ascites were randomly divided into treatment group and control group. 22 patients were treated with Compound Matrine injection and Cisplatin intraperitoneal perfusion( treatment group),and 20 patients were treated with Cisplatin intraperitoneal perfusion only( control group). The changes in volume of ascites and treatment side effects were observed. Results: The objective response rate( CR and PR) of treatment group and control group were 90. 9% and 65. 0% respectively,and the difference was significant( P 0. 05). The treatment group had a slighter side effect on abdominal pain,gastrointestinal rection and bone marrow depression,and the difference was significant( P 0. 05). Conclusion: The results suggest that intraperitoneal perfusion of Compound Matrine injection and Cisplatin is safe and effective in treating malignant ascites.
【CateGory Index】: R730.58
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