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《Journal of Modern Oncology》 2019-10
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The diagnostic value of detection of Geminin,Ki-67 and HPV for early cervical intraepithelial neoplasia

Yang Xufeng;Lei Longchun;Cheng Zhengyan;Department of Pathology,the East Ward of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital;  
Objective:To explore the diagnostic value of detection of Geminin,Ki-67 and HPV for early cervical intraepithelial neoplasia.Methods:Immunohistochemical SP method was used to detect the expression of Geminin and Ki-67 in 126 cases of cervical intraepithelial neoplasia(CIN),50 cases of chronic cervicitis,and 30 cases of normal cervical tissue.The HC2 method was used to detect the load of HPV.Using Spearman rank correlation analysed the correlation of the expression of Geminin,Ki-67 and HPV infection.Results:The positive expression rate of Geminin and Ki-67 in CIN tissues was higher than that in the cervicitis group and the control group(P0.05). There was no significant difference in the positive rate of Geminin and Ki-67 in the cervicitis group and the control group(P0.05).The positive rate of Geminin and Ki-67 in CIN tissues was CINIII groupCINII groupCINI group,and there was a significant difference between groups(P0.05).The positive expression rate of HPV in cervical lesions was CINIII groupCINII groupCINI groupcervicitis groupcontrol group,the difference in groups was statistically significant(P0.05).The expression of Geminin and Ki-67 was positively correlated with HPV infection(P0.05).The specificity and accuracy of the combined detection of Geminin,Ki-67 and HPV was the highest.Conclusion:The expression level of Geminin and Ki-67 and HPV infection rate in different CIN stage lesions are quite different.The early CIN can be diagnosed by combined detection of HPV,Geminin and Ki-67.
【CateGory Index】: R737.33
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