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《THE PRACTICAL JOURNAL OF CANCER》 2000-03
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The Relationship Between Cell Cycle Control Gene cyclin D1 and p16 and Lung Cancer

QIU Hong,SU Chang-qing. Department of Biochemistry,Nanjing 81 hospital,Nanjing,210002  
Objective To study the relationship between cyclin D1,p16 gene and lung cancer.Methods cyclin D1 and p16 genes in 40 cases of lung cancer were studied by multiplex PCR.Results The positive rate of cyclin D1 gene and p16 gene in lung cancer was 55.0%(22/40) and 65.0%(26/40) respectively.The positive rates of the two genes were related to lymph node metastasis and clinical stage of lung cancer.Conclusion cyclin D1 and p16 genes play an important role in lung cancer.Amplification of cyclin D1 gene and deletion of p16 gene are related to the high activity of cancer cells.
【CateGory Index】: R734.2
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【Citations】
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【Co-citations】
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1 PENG Mengqing, WANG Xu, LIU Delin, LUO Tao, CHEN Jie, HAO Xingzhi. Department of Radiology, The Affiliated Hospital, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R.China;Detection of methylation and deletion of p16 gene in non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2002-04
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