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《The Practical Journal of Cancer》 2002-04
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Experimental Study of Inhibitory Effect of Boanmycin on Human Esophageal Cancer and Others

TANG Hao,YANG Xiao-Ping. Department of Internal Medicine,Hubei Cancer Hospital,Wuhan,430079  
Objective To study the inhibitory effect of boanmycin on human esophageal cancer cell and other tumors in vitro and in vivo.Methods The cytotoxic effect of boanmycin on five human cancer cell lines was determined by MTT assay in vitro;Inhibitory effect of boanmycin on human esophageal cancer xenografts in nude mice was observed.Results Boanmycin has significant cytotoxic effect on these five cell lines in vitro.In the model of human esophageal cancer(HEC2) xenografts in nude mice,the inhibitory rates of boanmycin group(10.0 mg/kg and 15.0 mg/kg) were 85.2% and 90.6%.In the other model of human esophageal cancer(Eca-109) xenografts in nude mice,the inhibitory rates of boanmycin treated group(7.5 mg/kg and 15.0 mg/kg) were 81.2% and 92.0% respectively.Conclusion Boanmycin shows strong antitumor effect on human esophageal cancer and other tumors in vitro and in vivo.
【CateGory Index】: R735.1
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