Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Laboratory Animal Science》 2007-03
Add to Favorite Get Latest Update

A Study on the Toxicity of Maca Powder in Mice and Rats

TIAN Hui,FAN Be-Lin,SUN Fan-zhong,YANG Wen-xiang,LIU Yao,FU Shao-hua,TIAN Jie,GONG Chen-rui,WANG Yue,YANG Xian-lun,TANG Li-jun(Sanitation Test Institute,Hubei Provincial Center of the Control and Prevention of Diseases,Wuhan 430079,China)  
Objective Evaluate the security of Maca powder as a health food.Methods The acute toxicity test by oral administration,bone marrow micronucleus test,and sperm shape deformity test were carried out in SPF KM mice were performed,and Maca powder was administered to the Wistar rats for 90 days.Results In the male and female SPF KM mice with oral administration of Maca powder at the total dosage of 10 g/kg(corresponding to 300 times daily dosage in human),the obvious toxic symptoms and death were not found during observing for 2 weeks.The bone marrow micronucleus test,and sperm shape deformity test showed the negative results.In the female Wistar rats with oral administration of Maca powder for 90 days at the low dosage(1.51 g/kg,corresponding to 46 times dosage in human),the middle dosage(3.05 g/kg.corresponding to 93 times dosage in human),and the high dosage(6.16 g/kg,corresponding to 187 times dosage in human,and in the male Wistar rats with oral administration of Maca powder for 90 days at the low dosage(1.42 g/kg,corresponding to 43 times dosage in human),the middle dosage(2.87 g/kg.corresponding to 87 times dosage in human),and the high dosage(5.78 g/kg,corresponding to 175 times dosage in human),no obvious toxic effects were not found by the observations of clinical symptoms,hematological test,biochemical test,changes in weight of organs,and pathological examination.Conclusion The Maca powder can be securely taken as a special food.
【Key Words】: Maca powder Acute toxicity Bone marrow micronucleus test Sperm shape deformity test
【CateGory Index】: R114
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved