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《Laboratory Animal Science》 2010-02
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Effect of Sulfur Fumigated Dioscorea opposita Thunb on Oxidative Stress in Liver and Kidney of Rats

GUO Jie1,ZHOU Jing-yang1,YAN Yan1,ZHAO Hai-xia2,CHENG Dong1,YAO Wen-huan1(1.Shandong Center for Disease Control and Prevention,Jinan 250014,China)(2.Affiliated Hospital of Shandong University of Chinese Medicine,Jinan 250011,China)  
Objective To investigate the influence of sulfur fumigated Dioscorea opposita Thunb on peroxidation and antioxidation in liver and kidney of rats.Methods Wistar rats were divided randomly into 4 groups,one control and three experimental groups administrated diets mixed with concentrated extractions from unfumigated,commercial and sulfur fumigated Dioscorea opposita Thunb respectively.The level of MDA and activities of SOD and GSH-Px 14 weeks after treatment were measured.Results(1) Dioscorea opposita Thunb enhanced the activity of antioxidation;(2) Level of oxidative stress is different in liver and kidney,and depended on the concentration of sulfur fumigated Dioscorea opposita Thunb extractions.(3) There were sexual differences in levels of oxidation damage by Sulfur fumigated Dioscorea opposita Thunb,so did in various organs.Conclusion It is possible to cause lipid peroxidation in liver and kidmey by long-term use of Sulfur fumigated Dioscorea opposita Thunb.
【Fund】: 山东省中医药科技发展计划项目 编号:2007-051
【CateGory Index】: S567.239
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