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《Chinese Journal of Reproductive Health》 2003-03
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Study of Chinese drug Arnebia genotoxicity with micronucleus test

LI Xiaohong,YANG Liu,JI Keping,et al.Gansu College of Traditional Chinese Medicine,department of Anatomy and Histology & department of Gynicology of Traditional Chinese Medicine & department of Biology,Lanzhou 730000,China  
Objective To detect genetic toxicity of Chinese drug Arnebia decoction in adult and fetal mice. Methods Micronucleus test was employed on adult mice of bone marrow cells and fetal mice of hepatocytes. Results The frequency of micronucleated polychromatic erythrocytes on adult and pregnant mice were (3 8±1 0) ‰ and (3 8±1 4) ‰ respectively,after gastric perfusion of Arnebia decoction in dosage of 1 0 g/kg.There was no significant difference in comparison with negative control groups (t 1=0 9,t 2=2 1,P0 05).But significant micronucleus induction at the higher dose of 5 0 g/kg,10 0 g/kg and 20 0 g/kg were showed on adult and pregnant mice (7 1±1 8) ‰,(8 8±2 2) ‰,(9 3±1 8) ‰.Respectively compared with the negative controls (t 1=5 8,t 2=9 7,t 3=8 4,P0 01). Conclusion A genotoxic potential of Arnebia decoction was demonstrated in our study and was dose related.It should be aware the effects in clinical practice especially among pregnant population.
【Fund】: 甘肃省教育厅资助项目(编号 :949-0 5 )
【CateGory Index】: R285
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