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《Chinese Journal of Reproductive Health》 2017-02
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Cyclin dependent kinase inhibitor 2A2B gene and gestational diabetes mellitus

LI Lixian;XU Man;Department of Obstetrics,Shenzhen Maternal and Child Health Hospital;  
Objective To examine the association between the polymorphism in cyclin dependent kinase inhibitor2A/2B gene(CDKN2A/2b) and gestational diabetes mellitus(GDM).Methods 56 patients with GDM(GDM group),108 pregnant women with normal glucose tolerance(normal group),and 98 women with type 2 diabetes(T2DM)were selected in our hospital from December 2014 to 2015 December.DNA was extracted from fasting peripheral blood sample.Polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP) method was used to genotype CDKN2A/2b.Results TT,TC,and CC genotypes were observed in CDKN2A/2B gene rsl0811661 locus in all three groups.TT frequency in GDM and T2DM groups was significantly higher than that in the normal group(P 0.05).There was no difference in TT frequency between the GDM and T2DM groups.The normal group showed higher frequency of CC than the GDM group and the T2DM group;the GDM and T2DM groups had no difference.There was no difference in TC frequency among the three groups.T allele frequency was 48.6%in the normal group,which was significantly lower than in the GDM group(61.3%) and in the T2DM group(62.7%);however,the difference between the last two groups was not statistically significant.Correlation analysis showed that T allele was correlated with GDM(r = 4.227,P 0.05).Conclusion Polymorphism is present in CDKN2A/2b gene rsl0811661 locus.T allele may be a risk allele for GMD.CDKN2A/2b gene is a predisposing gene for GDM and as well as for T2DM.
【CateGory Index】: R714.256
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 HOU Xu-ben1,FANG Hao1,2,DU Jing-tong1,LIU Ning1,ZHANG Liang-ren2(1 School of Pharmacy,Shandong University,Jinan 250012,China;2 State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100191,China);Progress in clinical trails of cyclin dependent kinase inhibitors[J];中国新药杂志;2011-14
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 LI Lixian;XU Man;Department of Obstetrics,Shenzhen Maternal and Child Health Hospital;;Cyclin dependent kinase inhibitor 2A2B gene and gestational diabetes mellitus[J];中国生育健康杂志;2017-02
2 Tao Qingxia;Zhang Peng;Wu Cuiying;Sun Kai;Zheng Jianghua;Wang Chong;Weifang Medical University;The Affiliated Bayi Brain Hospital, PLA Army General Hospital;Ji’ning Medical University;Ji’ning No.1 People’s Hospital;;Recent research progress in the anti-tumor effect and mechanism of allicin[J];中华神经创伤外科电子杂志;2016-06
3 Ma Su-hao;Zhang Qiu-ying;Zhengzhou Shuqing Junior Medical College;;Effect of Tanshinone ⅡA for Vascular Smooth Muscle Cell CyclinD1 and CDK4 Expression[J];世界最新医学信息文摘;2016-94
4 FU Wen-feng;LIU Tian-reng;Department of Orthopedics,the First Affiliated Hospital of Nanchang University;;Progress in Treatment of Tumor with Cell Cycle Inhibitor[J];实用临床医学;2015-10
5 Han Fen1 Yang Xiao2 Shen Xiaojun2 Zhengzhou Railroad Occupation Technical College,Zhengzhou,Henan,China 450052 Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China 450046;Influence on Regulating Factor CyclinD1 and CDK4 Expression of Vascular Smooth Muscle Cell by TanshinoneⅡA[J];中医学报;2012-11
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 LI Wen-yun, ZHANG Lei, LI Fu-long, WANG Zhao-hui, YAO Qi-zheng (School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China);Research Advances in Anticancer Cyclin-dependent-kinase Inhibitors[J];国外医药(抗生素分册);2009-03
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