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《Journal of Practical Stomatology》 2004-01
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Expression of BMP2 and IGF1 in the periodontium of experimental regeneration a ffected by slow-releasing Shuanghuangbu strip

Xu Yanzhi, Wang Shijie,Zhang Dongmei, et al. Department of Stomatology, The Fou rth Hospital of Hebei Medical University, Shijiazhuang 050011,China  
Objective:To investigate the effect of Shuanghuangbu slow releasing strip (SRSS) on the expression of BMP2 and IGF1 in the experimental regeneration of periodontium. Methods:Periodontal defects were surgically made around the second incisor and the ca nine in four beagle dogs .32 defects were randomly divided into experimental gr oup and control group with 16 defects in each group. SRSS was applied to the e xperimental group and no disposition to periodontal defect in the control group. Two teeth of each dog were randomly chosen as the natural controls.Specimens we re respectively obtained one month and three months after operation. BMP2 and I GF1 were quantitatively analyzed by immunohistochemistry. Results:The positive rate of BMP2 and IGF1 in experimental group were higher t han those in the control( P 0.05) 1 month and 3 months after operation. Conclusion:SRSS can increase the expression of BMP2 and IGF1 in the periodontium.
【Fund】: 河北省科技厅资助课题(0 2 2 76 1 0 3D -19)
【CateGory Index】: R285
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