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《Journal of Practical Stomatology》 2010-01
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Effects of different skin expansion ways on collagen and actin

SHI Wenbin,DONG Yuying,DONG Fusheng,SHI Peikai,REN Guiyun,LI Jianying.050017 Shijiazhuang,College of Stomatology,Hebei Medical University,China  
Objective: To understand the effects of different expansion ways on collagen and actin of skin and to provide an experiment foundation for the suitable expansion method clinically.Methods: The rabbits were divided into five groups.The expanders were embedded in experimental group.The sirius-red specific staining method was applied to observe the changes of type I collagen and type III collagen and their proportion.Immunochemistry method was used to detect the expression of actin.Results: 1: In group A,B and C,type I collagen arranged turbulently and was thicker and type III collagen decreased relatively at earlier maintaining period.After 4 week,type I collagen arranged regularly and type III collagen was relatively increased.2: Comparisons of the area about type I,III collagen: At the same maintaining period,there were no significant difference among the group A,B and C.With the extension of maintaining period,the area of type I,III collagen increased gradually,but there was inclined to stabilize at the fourth week in group A,B and at the third week in group C.Comparison of the proportion of collagen I and collagen III: There were significant difference between group A,B and group D,but no significant difference was observed after the fourth week.There were significant difference between group C and control group,but no significant difference was observed after three week.3.With the extension of maintaining period,the positive expression rates of actin decreased gradually in group A,B,C.At the same maintaining period,significant difference were observed among group A,B,C.The positive expression rates of actin in group C were lower than that of group A at the same maintaining period.Conclusion: The repeated rapid expansion can not only shorten the clinical period but also promote the quality of skin flap.It is a safe and feasible method in clinic.
【Fund】: 河北省科学技术研究与发展计划项目(编号:08276101D-59)
【CateGory Index】: R78
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 WANG Ximei 1) , FAN Zhihong 2) , LIU Kai 3) , CHEN Yantang 1) 1)Department of Plastic Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2)Department of Plastic Surgery, the Affiliated Renji Hospital, the Second Shanghai Medical University, Shanghai 200127 3)Department of Plastic Surgery,the No.9 Affiliated People's Hospital, the Second Shanghai Medical University, Shanghai 200011;Changes of actin, myosin, and α-SMA in expanded skin of rabbits[J];Journal of Zhengzhou University(Science Medical);2003-05
2 Wang Fengming,Hu Tao,Zhou Xuedong.Key Laboratory of Oral Biomedical Engineering Ministry of Education,Sichuan University,Chengdu 610041,China;TGF-β1 induced actin cytoskeletal reorganization in human dental pulp cells[J];Journal of Practical Stomatology;2005-06
3 QIU Lin,et al ( Department of Burns and Plastic Surgery,College of Pediatrics,Chongqing Medical University);A study on collagen constitute and formation of hypertrophic scar in different age periods[J];Journal of Chongqing Medical University;2003-04
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Wan Ming-cai1, Feng Feng1, Wang Xin-wei1, Guo Jian-gang2, Zhu Tai-yong2, Huang Man-yu2, Bi Jun-hua2 1Osteomyelitis Department of Traditional Chinese Orthopedics and Traumatology Hospital in Luoyang, Luoyang 471002, Henan Province, China; 2Henan Institute of Traditional Chinese Orthopedics and Traumatology, Luoyang 471002, Henan Province, China;Metabolism of collagen Ⅰ and Ⅲ during wound healing using Shengjiye and vacuum assisted closure[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-33
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