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《Journal of Clinical and Experimental Medicine》 2013-13
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The related factors about plasma apelin-13 level,insulin resistance and hypertension of type 2 diabetes mellitus patients

CHEN Shu juan,CHAI Jie,LI Hai-yan. Department of Endocrinology,The Second People's Hospital of Shenzhen,Guangdong Shenzhen 518000,China.  
Objective To study the relationship between the plasma apelin-13 level,insulin resistance and hypertension of type 2 diabetes mellitus patients.Methods Thirty patients with type 2 diabetes mellitus in our hospital during the period from Dec 2011 to Dec 2012 were regarded as the observation I group.Thirty patients with type 2 diabetes mellitus combined with hypertension were regarded as the observation II group.Thirty healthy physical examination people in the same period were regarded as the control group.The levels of plasma apelin-13,fasting plasma glucose(FPG),fasting insulin(FINS),insulin resistance index(IR) and blood pressure were detected,compared and analyzed.Results Compared with the control group,the level of apelin-13 was obviously increased in the observation I group,which was significantly decreased in the observation II group(P 0.05).Compared with the observation I group,the level of apelin-13 was obviously decreased in the observation II group(P 0.05).There were negative relationship between the plasma apelin-13 and FINS,IR and SBP.Conclusion The level of plasma apelin-13 increased significantly in the type 2 diabetes mellitus patients and decreased obviously in the type 2 diabetes mellitus patients combined with hypertension.The level of plasma apelin-13 is negatively correlated with the FINS,IR and SBP.
【Fund】: 2012年深圳科技计划项目 项目名称:Apelin与糖尿病心脑血管疾病相关性的临床研究 项目编号:201202034
【CateGory Index】: R587.1;R544.1
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