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《Journal of Clinical and Experimental Medicine》 2013-23
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The clinical significance of plasma surfactant protein-D in patients with septic ARDS

ZHI De-yuan;DUAN Mei-li;ZHANG Shu-wen;Intensive Care Unit,Beijing Friendship Hospital,Capital Medical University;  
Objective To investigate the clinical implication of the dynamic change of plasma Surfactant protein-D( SP-D) in septic acute re- spiratory distress syndrome( ARDS) patients. Methods Plasma samples of patients with sepsis at various stages were analyzed prospectively. 40 consec- utive patients from Jan 2012 to Oct 2012 with sepsis were enrolled into this study. The samples were divided into two groups,group of systemic inflamma- tory response syndrome( SIRS)( the control group) and ARDS group according to the criteria of ARDS. Then the ARDS group were divided into 4 sub- groups,the mild,moderate,severe and terminal group according to the Berlin definition of ARDS. The correlations between the plasma samples of SP- D levels of enzyme- linked immunosorbent( ELASA) and patients' clinical features were analyzed. Results The SP- D level was higher in the mild ARDS patients than these in SIRS( 0. 723 ±0. 153 ng / ml vs 0. 510 ±0. 187 ng / ml,P 0. 05). As ARDS became seriously,the levels of plasma SP- D is progressive increase( ARDS mild vs. ARDS moderate: 0. 723 ±0. 153 ng / ml vs 1. 043 ±0. 198 ng / ml,P 0. 05; ARDS moderate vs ARDS severe: 1. 043 ±0. 198 ng / ml vs. 1. 343 ±0. 186 ng / ml,P 0. 05); ARDS moderate vs. ARDS severe: 24. 98 ±1. 65 ng / ml vs. 26. 18 ±2. 83 ng / ml,P 0. 05). The SP- D level was negatively correlated with PaO 2 / FiO 2( r =-0.436,P 0.05),and positively correlated with and AaDO 2,SOFA score and A- PACHEⅡ( r =0. 314,0. 321 and 0. 453,respectively,P 0. 05). Conclusion Level of sepsis patients' plasma SP- D may be helpful in the diagnosis of septic ARDS.
【CateGory Index】: R459.7
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