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《Journal of Applied Clinical Pediatrics》 2003-02
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The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension

ZHANG Chunyu, DU Junbao, YAN Hui, et al. Pediatric Department,Peking University First Hospital,Beijing 100034, P.R.China  
Objective To explore the regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension (HPH) in rats.Methods Wistar rats were randomly divided into control group (n=8), hypoxic group (n=5) and hypoxic+NaHS group (n=7). Hypoxia management was performed by putting rats into normothermic hypoxia chamber with oxygen concentration of (10±0.5)% for 6 hours everyday. NaHS (14 μmol/kg) was injected intraperitoneally into rats of hypoxic+NaHS group before hypoxia exposure. Three weeks later, right ventricular catheterization was performed to measure the pulmonary artery pressure. The wet weight ratio of right ventricle(RV) vs left ventricle(LV)+septum(SP), RV/(LV+SP) was also measured.Results The rats in hypoxia group developed obvious pulmonary hypertension after three weeks of hypoxia with right ventricle hypertrophy. Compared with rats in hypoxia group, the mPAP and RV/(LV+SP) all decreased significantly (16.3±2.8 mmHg vs 23.7±2.2 mmHg,0.31± 0.02 vs 0.41±0.03,P0.01 respectively).Conclusion Hydrogen sulfide could inhibit the elevation of pulmonary arterial pressure during the rat′s HPH.
【Fund】: 国家自然科学基金(项目编号 :30 0 70 796 30 2 71 373);; 国家重点基础研究规划 (项目编号:G2 0 0 0 0 5690 5);; 北京市自然科学基金 (项目编号 :70 1 2 0 2 1 )
【CateGory Index】: R363
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