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《Journal of Applied Clinical Pediatrics》 2004-05
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Expression of proliferating cell nuclear antigen in renal tissues of children with primary nephrotic syndrome

MA Zu-xiang 1, ZHAO Wei-ling 1, HE Xiao-jie 2,YI Zhu-wen 2 (1.Department of Nephrology, Shenzhen Children′s Hospital, Shenzhen 518026,China;2.Department of Pediatrics,the Second Xiangya Hospital, Zhongnan University,Changsha 410011,China)  
Objective To investigate the expression of proliferating cell nuclear antigen(PCNA) in renal tissues of children with primary nephrotic syndrome(NS),and elucidate the relationship between PCNA expression and cell proliferation in renal tissues from the children with primary NS.Methods Paraffin-embedded renal biopsy tissue sections from 39 patients with primary NS were examined by immunohistochemical staining with anti-PCNA monoclonal antibody,normal renal tissue sections from 6 nephrectomized patients with nephroma were selected as control. Possible correlation between the percentage of PCNA positive cells and the pathologic type , histopathological score, clinical indices (serum albumin ,serum cholesterol ,serum creatinine and 24 hours urine protein ) before renal biopsy of NS were evaluated separately .Results The percentage of PCNA positive cells in glomeruli and tubulom terstitium of NS patients was significantly higher than that of the control (P0.05);The percentage of PCNA positive cells in glomeruli or tubulointerstitium of NS patients was positively correlated with the histopathological score of glomeruli or tubulointerstitium separately, the correlation coefficient were 0.7482(P0.001) and 0.6502(P0.01);the percentage of PCNA positive cells in glomeruli was positively correlated with the serum cholesterol level of NS patients before biopsy, the correlation coefficient was 0.5713(P0.05 );the percentage of PCNA positive cells in tubulointerstitium was positively correlated with the amount of 24 hours urine protein of NS patients before biopsy, the correlation coefficient was 0.6625(P0.05).Conclusions The overexpression of PCNA in renal tissues from the children with primary NS can nhance cell proliferation in renal tissues,and PCNA is a sensitive index in judging the pathological injury degree and prognosis of primary NS. J Appl Clin Pediatr,2004,19(5):369-371
【CateGory Index】: R726.91
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