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《Journal of Applied Clinical Pediatrics》 2005-02
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Study on Gastric Activity and Influential Factors in Term Newborn Infants with Asphyxia

XU Hua,ZHANG Jun-Hong,WEI Ming,LI Xia,YANG Chun-min,ZHANG Ying-hui (Department of Pediatrics,General Hospital of Beijing Air Force,Beijing 100036,C hina)  
Objective To study the changable regularity in term newborns with birth asphyxia on gastri c myoelectrical activity and plasma motilin and serum nitric oxide(NO) concentration and to evaluate digestive motor function on newb orns with birth asphyxia and investigate the effective intervening countermeasur e. Methods Measured electrogastrography (EGG),plasma motilin and serum NO concentration in 29 term newborns with birth asphyxia after feedings,as compared with those of no rmal controls. Results The percentage of normal slow wave(PNSW) in the asphyxia group (35.35±22.511)% was significantly lower than that in the healthy subjects(49.78±18.80)%(P0 .05),but the percentage of unnormal slow wave(PUSW) was significantly increased as compared with normal controls,was separately(55.66±29.39)%,(31.99±13.79)%( P0.01).PNSW was significantly increased in the light asphyxia than that in the severe asphyxia (P0.05).The concentration of motilin was significantly lower in the asphyxia than that in controls, were separately(301.47±73.31)ng/ L,(436.58±185.57)g/L(P0.001),but the level of NO was enhanced in asphyxi a, there was signi- ficantly difference in both groups(110.61±13.75)μmol /L,(98.66±0.72)μmol/L (P0.01).Related analysis of experimental para- meter in the asphyxia group showed that there was prominently negative correla tion between the PUSW and the level of plasma motilin(P0.001),there was sig nificantly positive correlation between the PUSW and the concentration of serum NO(P0.01),there was notable negative correlation between the level of motil in and NO(P0.01). Conclusion Asphyxia newborns exist disordered of electrogastrography rhyme,motilin is low er and NO is enhanced,suggest some gastrointestinal symptoms in neonates with bi rth asphyxia may be relationship with unusual regulation of the nerve and body f luid. J Appl Clin Pediatr,2005,20(2):131-133
【CateGory Index】: R722.1
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