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《Journal of Applied Clinical Pediatrics》 2005-05
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Expression Level of Matrix Metalloproteinases, Tissue Inhibitor of Metalloproteinases and Activity of Nuclear Factor Kappa B in Different Phases of Bronchopulmonary Dysplasia

RONG Zhi - hui, CHANG Li - wen , QIAN Li - ling,LI Wen - bin (Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 , China)  
Objective To explore the expression level of matrix metalloprotemases( MMP-9), tissue inhibitor of metailoproteinases (TIMP-1) and the activity of nuclear factor-κB(NF-κB)in the lung tissue of infants with bronchopulmonary dysplasia (BPD)and the extracellular matrix degradation in the pathogenesis of BPD so as to explain the transcription mechanism of MMP-9. Methods Autopsy lung specimens were obtained from 29 infants hospitalized in NICU. Lung tissue HE staining and MMP-9, TIMP-1 and NF-κB were examined by immunohistochemistry. Among the 29 cases, 25 cases developed HMD or BPD and 4 cases had no lung disease. According to Dik WA, 11 patients were included in the acute phase, 7 in the regenerative phases, 2 in the transitional phase and 5 in the chronic phase. Results MMP-9 staining intensity increased in BPD group compared with control group. The ratio of MMP-9/TIMP-1 was significantly lower in the chronic phase( P 0.05) The expression of MMP-9 had positive correlation with NF-κB in the cell nu-clear( r = 0.742).Conclusions The imbalance MMP-9/TIMP-1 plays an important role in the development of BPD. NF-κB can upgrade the expression of MMP-9.
【Fund】: 国家自然科学基金项目资助(30471824)
【CateGory Index】: R722.1
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