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《Journal of Applied Clinical Pediatrics》 2005-07
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Expression of Matrix Metalloproteinases-3 in Mice with Viral Myocarditis and Role of Fosinopril

QIN Yuan-han, LIU Tang-wei, WU Wei-feng,PANG Yu-sheng,HU Peng,LIN Wei-xiong,LI Jia-quan (The First Affiliated Hospital of Guangxi Medical University, Nanning 530021,China)  
Objective To explore the expression of myocardial matrix metalloproteinase-3 (MMP-3) in mice with viral myocarditis (VM) and eveluate the role of fosinopril.Methods Fifty-seven four to six-week-old male Balb/c mice were divided into four groups randomly: group A, B, C and D. Mice in infected group (B,C and D) were inoculated intrapritoneally with 0.1 mL of Coxsackievirus B_3 (CVB_3 Nancy strain). After 24 h of inoculation, group C and D were treated with normal saline and fosinopril respectively. All mice were sacrificed on the fo urteenth day.Histological cross sections of heart were stained with hematoxylin-eosin and myocardial histopathplogic scores were counted under optical microscope. The expression of myocardial collagen was examined by immunohistochemicalanalysis and analyzed using a computer assisted procedure of samples of experimental viral myocarditis mice and the controls, and the mRNA expression of MMP-3 was detected by reverse transcription-polymerase chain reaction (RT-PCR). Results In group B and C, the mRNA expression of MMP-3 was upregulated significantly compared with those in group A ( P 0.05). The expression of myocardial collagen (Ⅰand Ⅲ) in group B,C was increased remarkably compared with controls. In group D, the mRNA expression of MMP-3 was downregulated significantly compared with those in group B ( P 0.05); The expression of myocardial collagen in group D was decreased remarkably compared with those in group B ( P 0.05).Conclusions The changes of myocardial MMP-3 were associated with myocardial pathologic lesion of VM. The mRNA expression of MMP-3 was downregulated and the expression of myocardial collagen was decreased remarkably by fosinopril.
【Fund】: 广西科学基金项目资助(0448048)
【CateGory Index】: R542.21
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