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《Journal of Applied Clinical Pediatrics》 2005-12
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Changes of Nitric Oxide and Endothelin-1 in Bronchoalveolar Lavage Fluid and Vein Blood of Neonate Infants with Meconium Aspiration Syndrome

TIAN Bao-li1,ZHAI Shu-fen1,LIU Cui-qing2,TANG Long-mei3,JIA Xi-qun2,LI Wen-jing2(1.Department of Neonatology,Handan Central Hospital,Handan 056001,China;2.Department of Neonatology,Children′s Hospital of Hebei Province,Shijiazhuang 050031,China;3.Department of Health Statistic,Hebei Medical College, Shijiazhuang 050017,China)  
Objective To explore the changes of nitric oxide(NO) and endothelin-1(ET-1) in bronchoalveolar lavage fluid(BALF) and vein blood of newborn infants with meconium aspiration syndrome(MAS),and the machanism of lung damage in MAS patients.Methods There were 29 MAS patients in group A with type Ⅱ acute respiratory failure who were requiring mechanical ventilation. There were 31 mild MAS cases who didn′t need mechanical ventilation in group B. Group C included 32 healthy newborns. Blood samples had been taken in 4 times(corresponding to equal toor less than 1days, 3 days, 5 days and 10 days after birth). Bronchoalveolar lavage was performed at group A at the 1 day, the 3 day and before stopping the mechanical ventilation.Nitriate recovery and radio-immunity were used to determine NO and ET-1 concentration.Results During the earily period of MAS patients, NO was increased and ET-1 decreased, during the following period, NO was endogenously produced.NO in BALF was increased ,and ET-1 was decreased following the disease progres. Conclusions During the earily period of MAS, low NO and high ET-1 may be associated with the hypoxemic and pulmonary hypertension. During the following period, high NO is likely to react with the ongoing pulmonary inflammation and the chronic lung disease.
【CateGory Index】: R722.1
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