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《Journal of Applied Clinical Pediatrics》 2006-02
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Neuroprotective Effect of Recombinant Human Erythyropoietin Theraphy for Neonatal Hypoxic-Ischemic Encephalopathy

KANG Wen-qing~1,ZHU Chang-lian~2,XIONG Hong~1,CHENG Xiu-yong~2,WANG Xiao-yang~2(1.Department of Neonatology,Zhengzhou Children′s Hospital,Zhengzhou 450053,China;2.Department of Pediatrics,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)  
Objective To evaluate the neuroprotective effect and safety of neonatal hypoxic-ischemic encephalopathy(HIE)treated with recombinant human erythropoietin(rhEPO).Methods Fifty-three neonates with HIE were randomly divided into rhEPO treated group(n=29) with the dosage of 300 U/(kg·time),three times a week for 2 weeks and control group(n=24)without rhEPO.All supportive measures were same between 2 groups.Neurological scoring was evaluated at d3,d5 and d7 Neonatal behavioral neurological assessment(NBNA) was evaluated at d7,d14 and d28.The neurodevelopment quote was evaluated at age of 3 and 6 months.Blood pressure,liver and renal function,blood electrolytes and blood hemoglobin,platelet and reticular red blood cell count were monitored before and after treatment in all infants.Results The neurological scoring between two groups had no difference at d3.The significant difference was found at d7(P0.05).The scoring of NBNA showed a significant difference at all the evaluation times(P0.05).The neurological scoring at d7 and NBNA at d14 had no statistic difference among 3 groups with different starting treatment time.The neurodevelopment quote was significantly higher in rhEPO treated group than that in control group at age of 3 and 6 months.There were no differences in the liver and renal function,blood electrolytes,blood pressure and platelet count between two groups after treatment,except the hemoglobin and reticular red blood cell count increased in rhEPO treated group(All P0.05).Conclusions Teraphy with rhEPO on neonatal HIE infants can promote neurological recovery,and there is no serious side effect with rhEPO treatment.
【Fund】: 河南省重大科技攻关项目资助(0122032100);; 河南省医药卫生创新人才基金项目资助(2004107048)
【CateGory Index】: R722.12
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