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《Journal of Applied Clinical Pediatrics》 2006-13
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Protective Effects of Quercetin on Daunorubicin-Induced Cardiomyocyte Injury

ZHOU Lei,LAI Yong-hong (Department of Pediatrics,the First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China)  
Objective To investigate the protective effects of quercetin on primary cultured SD neonate rats cardiomyocyte injury induced by daunorubicin.Methods Cultured cardiomyocytes were divided into blank groups,DNR groups,DNR+QUE groups,QUE groups.After preincubation of cardiomyocytes for 24 hours,cytoprotection effect was assessed by cell morphous,and cell apoptotic rates determined by flow cytometry,extracellular lactate dehydrogenase(LDH),superoxide dismutase(SOD) and malondialdehyde(MDA).Results Compared with DNR groups,the shedded cardiomyocytes and the cell debris of DNR+QUE groups decreased;the cardiomyocyte apoptosis rates decreased;the content of LDH and MDA decreased(P0.05);the activity of SOD increased(P0.05),and there was dose-effect relation.Conclusions Quercetin with concentration between 25-100 μmol/L can lessen cardiomyocyte injury induced by daunorubicin,and the cytoprotection effect may be due to its antioxidation.
【Fund】: 广东省自然科学基金项目资助(5002733)
【CateGory Index】: R285
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Chinese Journal Full-text Database 3 Hits
1 YANG Dong-sheng1,XIE Xiao-hong2,LUO Xian-qun1(1.Department of Bioengineering,College of Science and Technology,Hainan University,Haikou 570228,China;2.Hainan Province People's Hospital,Haikou 570311,China);Research Advance on Application of Bioactive Constituent of Eucalyptus Leaf Extract and Flavonoids from Hainan Eucalyptus Urophylly[J];Chemistry & Bioengineering;2007-06
2 ZHANG Guang-mou,ZHANG Yan-fen,XU Chong-jie,et al(1.Department of Cell Biology and Genetics,Xinxiang Medical College,Xinxiang 453003,China);Expression of telomerase reverse transcriptase in myocardial cell of rats with heart failure[J];Journal of Xinxiang Medical College;2008-02
3 PEI Tian-xian1,XU Chang-qing1,4,YU Jing2,LI Hong-zhu1,GUO Jin1,GAO Xiu-xiang1,ZHAO Wei-ming2,YANG Bao-feng3,4( 1.Dept of Pathophysiology,2.Dept of Biochemistry,3.Dept of Pharmacology,Harbin Medical University,4.Bio-pharmaceutical Key Laboratory of Heilongjiang Province,Harbin 150086,China);Effect of quercetin on rat cardiomyocyte apoptosis induced by adriamycin in vitro[J];Chinese Pharmacological Bulletin;2008-04
Chinese Journal Full-text Database 3 Hits
1 TAN Xiao-rong, ZHANG Wei-min, GONG Zheng-li (College of Food Science, Southwest University, Chongqing 400716, China);Research Advance of Functions and Properties of Ouercetin[J];Journal of Cereals & Oils;2005-11
2 Cao Wenjun, Chen Ruifen, Liu Guozhen Department of Pathology, Capital University of Medical Sciences;Protecting Effects of Quercetin on Myocardium Ischemia Repurfusion Injury in Rats[J];Journal of Capital University of Medical Sciences;2004-03
3 LAI Yong-hong,ZHAI Ying-ying,YE Tie-zhen (Department of Pediatrics,The First Affiliated Hospital of Guangzhou Medical Co llege,Guangzhou 510120,China);Protective Effect of Quercetin on Daunorubicin-induced Myocardial Injure[J];Journal of Modern Clinical Medical Bioengineering;2005-01
Chinese Journal Full-text Database 10 Hits
1 ZHOU Lei,LAI Yong-hong*,ZHAI Ying-ying,YE Tie-zhen(Department of Pediatrics,First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China);The Protective Effects of Quercetin on Drug-induced Myocardial Injury[J];Academic Journal of Guangzhou Medical College;2006-04
2 SHI Hui-xia,JIANG Gang~*,GAO Tao,ZHU Zheng-he(1.Institute of Atomic and Molecular Physics,Sichuan University,Chengdu 610065,China);Theoretical study on the structures and properties of quercetin and its isomers[J];Chemical Research and Application;2006-10
3 ZHU Bo,LI Hong-xia,ZHANG Ling-yun,et al(1.The Power Hospital of Heilongjiang Province,Harbin 150092;2.Department of Pathophysiology,Harbin Medical University,Harbin 150081,China);Protective effect of quercetin on hydroperoxide-induced neonate rat myocardial injury[J];Journal of Harbin Medical University;2006-06
4 GAO Fengying Institute of Hematology,Weifang Medical College Weifang 261000 YU Minkai Department of Hematology,People's Hospital Affiliated to Weifang Medical College,Weifang,Shandong 261041;Progress of Multidrug Resistance Mechanisms in Acute Leukemia[J];Chinese Journal of Clinical Medicine;2007-03
5 YANG Tao1,DUAN Cheng-li1,3,YANG Sheng-chao1,WEN Guo-song1,ZENG Ya-wen2,XIAO Feng-hui1,3(1.Institute of Chinese Medical Materials of YAU,Yunnan Provincial Center for Chinese Medicinal Materials,GAP Technology,Kunming,Yunnan 650201,China;2.Biotechnology and Genetic Resources Institute,Yunnan Academy of Agricultural Sciences,Kunming,Yunnan 650205,China;3.School of Forestry and Bio-technology,Zhejiang Forestry University,Hangzhou 311300,China);HPLC Determination of Catechin,Myricetin,Quercetin and Kaempferol in Barley Grain[J];Journal of Triticeae Crops;2009-04
6 YU Qing CHEN Shao-jun PANG Jie(The College of Food Science, Fujian Agriculture and Forestry University, Fuzhou,Fujian 350002,China);The effective components and utilization of vaccinium bracteatum Thunb.leaf[J];Food & Machinery;2007-03
7 LIU Shu-xing, ZHAO Fang (Shaanxi University of Science and Technology,Xi'an 710021,Shaanxi, China);RESEARCH PROGRESS ON NATURAL ANTIOXIDANT FROM NATURE PLANT[J];Food Research and Development;2007-07
8 GE Rui,LI Qing-shan,ZHAO Liang.Pharmaceutical Institute,Shanxi Medical University,Taiyuan 030001,China;The protective effects of Haihongguo flavonoids on the injury myocardial ischemia induced by pituitrin[J];Shanxi Medical Journal;2007-04
9 YANG Rui, CHEN Zheng-yue, WANG Shu-xiu (Moliecular Biology Laboratory; Pharmaceutical Laboratory; Deparment of Pathology, Xinxiang Medical College, Xinxiang 453003, China);Construction of Prokaryotic Plasmid of Mycobacterium Tuberculosis Heat Shock Protein 70 and Characterizing Its Antitumor Role[J];Journal of Applied Clinical Pediatrics;2006-10
10 YE He-yang~(1,2),WANG Xiu-rong~1,HUANG Zhi-hua~1,ZHOU Li~1,HE Wei~1,ZENG Jing~1(1.Department of Pharmacology,Gannan Medical College,Ganzhou,341000 China;2.Huazhong University of Science and Technology,Wuhan 430074,China);The Protective Effect of Polygonum Bistora L.n-Butyl Alcohol Extract on Myocardial Ischemia[J];LiShiZhen Medicine and Materia Medica Research;2006-06
Chinese Journal Full-text Database 10 Hits
1 ZHENG Ji~ 1 , ZHANG Xi-lian~ 1 , ZHOU Jun-li~ 1 , DANG Yong-ming~ 1 , ZHANG Jia-ping~ 1 , LIU Chun-yu~ 2 ,~ ZHANG Dong-xia~ 1 ,~ SONG Hua-pei~ 1 , ZHANG Qiong~ 1 , HUANG Yue-sheng~ 1 (~ 1 State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burns, ~ 2 Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Effects of microtubule disassembly on hypoxic injury of cultured cardiomyocytes[J];Acta Academiae Medicinae Militaris Tertiae;2006-07
2 Cheng Cangcang Fu Jieyuan Yue Qian Zhang Xin Hu Dewen Wan Kun(School of Chemistry and Environmental Engineering,Jianghan University, Wuhan 430056);Study on photocatalytic degradation of bisphenol A using TiO_2 thin film[J];Techniques and Equipment for Environmental Pollution Control;2005-07
3 ZHAN Manjun 1,2, YANG Xi 1,, YANG Hongsheng, KONG Lingren 1.State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093 2.Department of Chemistry, Jiaying University, Meizhou 514015;Study on the effect of natural aquatic humic substances on the photodegradation of bisphenol A[J];Acta Scientiae Circumstantiae;2005-06
4 ZHANG Hao-yi,JIANG Quan,JIN Hui,HE Ling * (West China School of Pharmacy,Sichuan University,Chengdu 610041,China);Extraction of rutin from Sophora japonica L. by microwave irradiation[J];West China Journal of Pharmaceutical Sciences;2004-01
5 CHENG Cang-cang~1,DENG Nan-sheng~2,WU Feng~2,LIU Li~1,WAN Kun~1,ZHOU Ju-xiang~1(1.School of Chemistry and Environmental Engineering,Jianghan University,Wuhan 430056;2.School of Resources and Environment,Wuhan University,Wuhan 430072);Study on photoelectrocatalytic degradation of bisphenol A[J];Journal of Central China Normal University(Natural Sciences);2005-03
6 FANG Fang,ZHANG Lan-ying,YANG Xue-mei,ZHANG Yu-ling,LIU Xiu,SONG Ying(College of Environment and Resources,Jilin University,Changchun 130061,China);Screen of Bacteria High-effectively Degrading Bisphenol A and Its Degradation Characteristics[J];Journal of Jilin University (Science Edition);2005-06
7 ZHANG Guang-Mou,GUO Zhi-Kun,XU Zhen-Ping,WEN Xiao-Jun,WANG-Hua(Department of Cell Biology,Xinxiang Medical College,Xinxiang 453003,China);Expression of telomerase reverse transcriptase and telomeric repeat binding factor 2 during rat myocardial development[J];Chinese Journal of Anatomy;2005-02
8 ZENG Rong~ 1,2, ZHANG Jian~1, TAN Xiang-hong~1, LUO Xue-gang~2(1.College of Forestry and Horticulture, Sichuan Agricultural University, Yaan 625014, Sichuan, China;2.Southwest University of Science and Technology, Mianyang 621000, Sichuan, China);Determination of Rutin in Eucalyptus youmanii by Spectrophotometric Method[J];Journal of Sichuan Agricultural University;2005-02
9 Qiao Jin,Zhang Zhao-yong,Wang Ke-dong(Lu'nan Pharmaceutical Share Limited Corporation, Linyi, 276005);Extract Rution from Japanese Pagodatree Flower-bud by mass trial[J];Shangdong Pharmaceutical Industry;2004-07
10 Liu Shuxing Wei Lina Wang Wei(College of Life Science and Engineering,Shaanxi University of Science & Technology,Xianyang 712081,China);Technology of Extracting Rutin from the Old Stalk of Asparagus[J];Food and Fermentation Industries;2005-12
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 DENG Fang-ge1,LU Dong-xiao2,ZHANG Xiu-ying3,LI Yu-lin3 (1Guangzhou Institute of Respiratory Diseases,2Department of Cardiology,First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120;3Ministry of Education Key Laboratory of Pathology,Jilin University,Changchun 130021,China);Construction of Noninvasive Myocardial Ischemia and Hypoxia Model in Immunodeficient Athymic Mice[J];Academic Journal of Guangzhou Medical College;2008-04
2 YAO Jie,SHENG Shu-li,JI Zhi-juan,ZHAO Zhi-wei,LIU Meng-xia,WANG Rong(Xuanwu Hospital of Capital Medical University,Education Ministry Key Laboratory forNeurodegenerative Disease,Beijing 100053,China);The effects of polypeptide P165 on the learning and memory function and the protein expressions in hippocampal neuron of diabetic mice[J];Chinese Pharmacological Bulletin;2009-03
3 ZHU Xiao-jie,LIANG Fei,WANG Xiu-hong,ZHAO Wei-ming,GAO Xu(Dept of Biochemistry and Molecular Biology,Harbin Medical University,Harbin 150086,China);Protective effect of COPP on hypoxia/reoxygenation injury of H9c2 myocytes[J];Chinese Pharmacological Bulletin;2009-03
4 YANG Dong-sheng1,HUANG Bei-lei1,XIE Xiao-hong2,LUO Xian-qun1(1.Department of Bioengineering College of science and Technology,Hainan University,Haikou 570228,China;2.Hainan Province Hospital,Haikou 570311,China);The method of extraction of flavonoids from Hainan Eucalyptus urophylly leaf[J];China Food Additives;2007-06
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 Zhang Qiong, Xu Mingjuan, Song Liangnian, Wang Zhaomei (Department of Gynecology and Obstetrics, Changhai Hospital, Second Military Medical University, Shanghai, 200433);Effects of quercetin on the proliferation of 3AO: a human ovarian carcinoma cell line[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1999-06
2 Wu Chengtang; Li Zhanliang; Xiong Dexin(Department of General Surgery, Nanfang Hospital, First Military Medical University, Guangzhou, 510515; Department of GeneralSurgery, The 304th Hospital of PLA, Beijing, 100037);Changes of intestinal permeability and histologies of intestinal mucosa in acute necrotizing pancreatitis in dogs[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;1999-01
3 HUANG Liang,JI Xianfei,CAO Chunshui,et al.Department of Emergency medicine,the First Affiliated Hospital of Jiangxi Medical College,Nanchang 330006,China;Protective effects of quercetin in rats with lipopolysaccharide-induced acute lung injury[J];Journal of Emergency Medicine;2004-02
4 Chen Meng, Yuan Dongxing, Xu Pengxiang(Environmental Science Research Center, Xiamen University, Xiamen 361005);Research Progress on Microwave Extraction[J];JOURNAL OF INSTRUMENTAL ANALYSIS;1999-02
5 WANG Yan fang 1,WANG Xin hua 2,ZHU Yu tong 2 ( 1.Guangzhou University of Traditional Chinese Medicine ,Guangzhou 510405,China; 2. Tropical Medicine Institute of Guangzhou University of TCM ,Guangzhou 510405,China);ADVANCEMENT OF RESEARCHES IN QUERCETIN[J];Natural Product Research and Development;2003-02
6 SU Jun feng,GUO Chang jiang,WEI Jing yu, et al . (Institute of Hygiene and Environmental Medicine, Tianjin 300050,China);COMPARATIVE STUDY ON THE ANTIOXIDANT CAPACITY OF QUERCETIN IN VIVO AND IN VITRO[J];Chinese Journal of Applied Physiology;2002-04
7 Lin Rong,Liu Juntian,Li Xu,et al. Center of Molecular Biology,the First Affiliated Hospital of Xi'an Medical University,Xi'an(710061),Shaanxi;Protection of Vascular Endothelial Cells from Hydrogen Peroxide Induced Injury by Quercetin[J];CHINESE CIRCULATION JOURNAL;2000-05
8 Xu xiangjin,Zhang Jiaqing,Huang Qinling,Department of Endocrinology, Fuzhou General Hospital of PLA,Fuzhou,350025;Effect of quercetin on inhibition of non enzymatic glycation and oxidation in kidney of streptozotocin induced diabetic rats[J];CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM;1998-01
9 PENG Ying Xu 1 , ZHUANG Yan Li 1, LIAO Gong Tie 2 (1. Shanghai Institute of Pharmaceutical Industry, Shanghai 200437; 2. School of Pharmacy, West China University of Medical Sciences, Chengdu 610041);Study on Bone Marrow Targeting Daunorubicin Polybutylcyanoacrylate Nanoparticles[J];CHINESE JOURNAL OF PHARMACEUTICALS;2000-02
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