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《Journal of Applied Clinical Pediatrics》 2006-13
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Protective Effects of Quercetin on Daunorubicin-Induced Cardiomyocyte Injury

ZHOU Lei,LAI Yong-hong (Department of Pediatrics,the First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China)  
Objective To investigate the protective effects of quercetin on primary cultured SD neonate rats cardiomyocyte injury induced by daunorubicin.Methods Cultured cardiomyocytes were divided into blank groups,DNR groups,DNR+QUE groups,QUE groups.After preincubation of cardiomyocytes for 24 hours,cytoprotection effect was assessed by cell morphous,and cell apoptotic rates determined by flow cytometry,extracellular lactate dehydrogenase(LDH),superoxide dismutase(SOD) and malondialdehyde(MDA).Results Compared with DNR groups,the shedded cardiomyocytes and the cell debris of DNR+QUE groups decreased;the cardiomyocyte apoptosis rates decreased;the content of LDH and MDA decreased(P0.05);the activity of SOD increased(P0.05),and there was dose-effect relation.Conclusions Quercetin with concentration between 25-100 μmol/L can lessen cardiomyocyte injury induced by daunorubicin,and the cytoprotection effect may be due to its antioxidation.
【Fund】: 广东省自然科学基金项目资助(5002733)
【CateGory Index】: R285
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