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《Journal of Applied Clinical Pediatrics》 2006-23
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Significance of Changes of Blood T-Lymphocyte Subsets in Neonates with Hypoxic-Ischemic Encephalopathy

WANG Jun,ZHANG Shao-mei(Department of Pediatrics,the Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,China)  
Objective To analyze the changes of T-lymphocyte subsets of neonates with hypoxic-ischemic encephalopathy(HIE)and its clinical significance.Methods Sixty-seven neonates with HIE were divided into 1-3 days group and 4-6 days group.In each group,it was divided into mild group and moderatesevere group,and 30 normal neonates as control group.T-lymphocyte subsets in peripheral blood were detected by flow cytometry(FCM).T-lymphocyte subsets of the acute(3-6 d)and recovery stage(14-20 d) of 9 moderate-severe neonates with HIE were detected too.Results In 1-3 days group:percentages of CD3+ and CD4+ cells in neonates with HIE were significantly lower than those in control group(P0.01,0.05),but there was no significant difference between mild HIE group and moderate-severe HIE group(P0.05),and there was no obvious difference of CD4+/CD8+ between these groups(P0.05).In 4-6 day group:percentages of CD3+ and CD4+ cells and ratio of CD4+/CD8+ in neonates with HIE were all obviously lower than those in control group(P0.01),but there was no significant difference between mild HIE group and moderate-severe HIE group(P0.05).The level of percentages of CD3+ and CD4+ cells and ratio of CD4+/CD8+ in 9 subjects with moderate-severe HIE were remarkably higher during recovery stage than those during acute stage(P0.05).Conclusion T-lymphocyte subsets are restrained in neonates with HIE,especially for CD3+,CD4+ cells,but may be improved by reasonable therapy.
【Fund】: 江苏省教育委员会自然科学基金指导性课题项目资助(99KJD320001)
【CateGory Index】: R722.1
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