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《Journal of Applied Clinical Pediatrics》 2007-02
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Risk Factors of Bronchopulmonary Dysplasia in Very Low Birth Weight Infants

CHEN You,YE Zhen-zhi,LU Guang-jin(Department of Neonatology,Bao'an Maternal and Child Health Hospital of Shenzhen,Shenzhen 518000,China)  
Objective To investigate the risk factors,prevention and treatment of bronchopulmonary dysplasia(BPD) in very low birth weight infants(VLBWI).Methods A retrospective study was performed in VLBWI with mechanical ventilation and hospitalized more than 28 days.More than 20 factors were analyzed as the risk factors of BPD.Results The overall incidence of BPD in VLBWI with mechanical ventilation and hospitalized more than 28 days was 41.07%(23/56),and 17.04%(23/135)in those VLBWI who received mechanical ventilation,and 6.20%(23/371) in those infants whose birth weight ≤1 500 g.FiO_2,peak inspiratory pressure(PIP),positive end-expiratory pressure(PEEP),mean airway pressure(MAP),the days of starting mechanical ventilation,maternal prenatal administration of dexamethasone and usa -ge of pulmonary surfactant to newborn had no significant differences between BPD and control groups(P_a0.05).But there were significant differences in gestational age less than or equal to 30 weeks,birth weight less than 1 250 g,times of mechanical ventilation treatment (≥2 times),pulmonary infection,pneumorrhagia,prolonged mechanical ventilation(≥5 days) and positive culture of the lower respiration secretion more than 2 times(P_a0.05);Multivariate logistic analysis revealed that pulmonary infection with regression coefficient 0.952,odd ratio(OR)2.591;the days prolonged mechanical ventilation with regression coefficient 0.144,OR 1.154.Conclusion Shortening the duration of mechanical ventilation to prevent pneumonia,particularly serious pnenumonia,is important in preventing BPD.
【CateGory Index】: R722
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