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《Journal of Applied Clinical Pediatrics》 2007-02
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Experimental Study of Ventilator-Induced Lung Injury and Oxygen Inhalation in Newborn Rabbits

HUA Shao-dong,DU Jiang,LIU Xiu-xiang,TANG Wen,YANG Li-hua,FANG Zhi-chun(Department of Pediatrics,Zhujiang Hospital Affiliated to Southern Medical University,Guangzhou 510282,China)  
Objective To investigate the pathological change of ventilator-induced lung injury and oxygen inhalation and the regularity of white blood cell changes in broncho alveolar lavage fluid(BALF).Methods One hundred and eight newborn rabbits were divided randomly into two groups according to high concentration oxygen(FiO_2=1.0) and low concentration oxygen(FiO_2=0.45).Each group was sub-divided into three parts:high peak inspiratory pressure group (HPIP),moderate peak inspiratory pressure group (MPIP)and low peak inspiratory pressure group (LPIP). All rabbits were given mechanical ventilation(MV) and killed to obtain lungs at 1, 3, 6 hours after trail respectively. Cells in BALF were counted and the percentage of WBC was classified in sediment film. The ratio of wet to dry of lungs was detected, at the same time,pathological section was analyzed.Results The findings were demonstrated within 6 hours in newborn rabbits by MV. The white blood cell count ventilated with hyperxia or hypoxia groups was higher than that of control group(no MV);and that of HPIP group was higher than that of MPIP and LPIP groups (P_a0.05).The main percentage of WBC in BALF was macrophage in hypoxia or MPIP ventilation or that in control group. The percentage of leukomonocyte had irrelative with oxygen concentration, but it concerned with the lung mechanical stretch and the mean value was maximum under the condition of HPIP ventilation(P0.05); Compared to hypoxia groups ,segmented cell in hyperxia groups was higher.The percentage of segmented cell of MPIP groups significantly decreased than that of HPIP and LPIP groups(P_a0.05).Pathological ranking and score in newborn rabbits lung manifested that the lung injury in hyperxia groups was more severe than that of hypoxia groups.The lung injury of MPIP ventilation groups was lightest in all of experiment groups .All experiment rabbits pathological section had alveoli pulmonum heterogeneity inflation .There were obviously part pulmonary atelectasis in LPIP groups and pulmonary hemorrhage and pulmonary bullae formation in HPIP group.Conclusions When newborn rabbits suffer from MV,atelectasis is likely in the LPIP ventilation and barotrauma in the HPIP ventilation. Only MV with the MPIP can reduce the lung injury. Different cell responsees in BALF are determined by the different ventilation way.
【Fund】: 广东省科技计划项目基金资助(B30502)
【CateGory Index】: R722.1
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