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《Journal of Applied Clinical Pediatrics》 2007-16
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Expression of Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 in Fibra Muscular Torticollis in Children

LI Jun-zhang,XUE Ke-xiu,WANG Tian-xiao(Department of Orthopaedics,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,China)  
Objective To explore the expressions of matrix metalloproteinases-1(MMP-1) and tissue inhibitor of metalloproteinase-1(TIMP-1) in sternomastoid muscle and explore the pathogenesis of sternomastoid muscle fibrosis in congenital fibra muscular torticollis in children.Methods The hyperplastic state of collagen fiber were determine by Masson collagen stainning method and muscular torticollis and fibra torticollis was differed,obtained 22 cases of the fibra torticollis group.Immunohistochemical method was used to determine the expression of MMP-1 and TIMP-1 in sternomastoid muscle of fibra torticollis and compared them with 6 cases of control group.Results By the immunohistochemical method,the expression of MMP-1 in the experiment group significantly decreased than that in control group(P0.01),but the expression of TIMP-1 was no significant difference between 2 groups(P0.05).Conclusion In congenital fibra torticollis,the sternomastoid muscle fibrosis is related to the decrease of MMP-1.
【Fund】: 河南省科技攻关项目资助(052410057)
【CateGory Index】: R726.8
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