Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Applied Clinical Pediatrics》 2007-21
Add to Favorite Get Latest Update

Significance of Expression of Matrix Metalloproteinase 1 in Peripheral Blood of Children with Kawasaki Disease

HUANG Pei(Department of Pediatrics,People′s Hospital of Jurong City,Jurong 212400,China)  
Objective To explore the potential role of matrix metalloprotenase-1(MMP-1) in the pathogenesis of coronary artery lesions(CAL)in children with Kawasaki disease(KD).Methods Thirty-six children with KD,including 21 children without CAL and 15 children with CAL,as well as age-matched 10 healthy afebrile controls were studied.The courses of KD were divided into 3 phases:the acute phase,the subacute phase and the convalescent phase.Enzyme-linked immunosorbent assay was used to detect the protein level of MMP-1 in the sera.Results Levels of MMP-1 protein in serum were significantly elevated during the acute phase in 2 groups of KD children,compared with afebrile controls(Pa0.01).Furthermore,MMP-1 protein level was significantly higher in KD patients with CAL than that in KD without CAL(P0.05).There was significantly positive correlation between the serum level of MMP-1 in the acute phase of KD and the circulating leucocytes counts(r=0.791 P0.01).MMP-1 serum protein level in the acute phase of the 2 KD groups decreased obviously from the subacute through the convalescent phases(P0.01).Conclusion The measurement of serum MMP-1 may be of important clinical value in the prediction and early diagnosis of KD with coronary artery lesion.
【CateGory Index】: R725.4
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 CHEN Rui,ZHANG Ai-Rong,ZHAO Xin-Xi,LI Zhan-Hua.Zhumadian Central Hospital,Zhumadian,Henan 463000,China;Roles of matrix metalloproteinases,tissue inhibitor of matrix metalloproteinase and hs-CRP in Kawasaki disease[J];Chinese Journal of Contemporary Pediatrics;2009-12
2 ZENG Jun,CHEN Zhao-hong(Department of Pediatrics,Guangzhou Women and Children's Medical Center,Guangzhou 510120,Guangdong Province,China);Clinical Significance and Expression of Serum Matrix Metalloproteinase-9 in Children with Kawasaki Disease[J];Journal of Applied Clinical Pediatrics;2009-21
【Citations】
Chinese Journal Full-text Database 2 Hits
1 HOU Yuan-jie,XUE Ke-xiu(the Third Affiliated Hospital of Xinxiang Medical College,Xinxiang,453003,China);Advances of study on efeects of matrix metalloproteinases and its tissue inhibitors on tissue fibrosis[J];Journal of Xinxiang Medical College;2006-02
2 PENG Qian, ZHOU Tong-fu, CHEN Chang-hui, HUA Yi-min, LIU Han-min, HONG Hua, ZHANG Ling-ying, WU Qing.Department of Pediatrics, The People′s Hospital of Sichuan Province, Chengdu 610072, China;Clinical value of serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 for the prediction and early diagnosis of coronary artery lesion in patients with Kawasaki disease[J];Chinese Journal of Pediatrics;2005-09
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Xiao-lin,ZOU Zheng,ZOU Da-wei(The Children's Hospital of Jiangxi Province,Jiangxi Nanchang 330006,China);Glucocorticoid and Kawasaki Disease[J];Journal of Pediatric Pharmacy;2009-04
2 SHEN Jie,LI Jin-kang,HUANG Min,HUA Yang-de,YANG Xiao-dong,CHEN Xiu-yu,LIU Jia-ying(Department of Cardiology,Shanghai Children's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200040,China);Serum levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in children with Kawasaki disease[J];Journal of Clinical Pediatrics;2007-08
3 YANG Shi-wei,WANG Da-wei,QIN Yu-ming,CAO Li-ming,LI Jun(Department of Cardiology,Nanjing Children′s Hospital Affiliated to Nanjing Medical University,Nanjing 210008,China);Effects of All-Trans Retinoic Acid on Matrix Metalloproteinase-9 and Tissue Inhibitor of Matris Metalloproteinase-1 Expressions in Peripheral Blood Mononuclear Cells from Acute Kawasaki Disease Children[J];Journal of Applied Clinical Pediatrics;2006-21
4 LI Jun-zhang,XUE Ke-xiu,WANG Tian-xiao(Department of Orthopaedics,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,China);Expression of Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 in Fibra Muscular Torticollis in Children[J];Journal of Applied Clinical Pediatrics;2007-16
5 LEI Feng-ying,QIN Yuan-han,PEI Juan,HU Peng(Department of Pediatrics,the First Hospital Affiliated to Guangxi Medical University,Nanning 530021,China);Expression and Significance of Matrix Metalloproteinase and Tissue Inhibitor of Metalloproteinase-1 in Rats with Glomerular Sclerosis[J];Journal of Applied Clinical Pediatrics;2007-23
6 GUO Ai-ling1,TIAN Pei-chao2,WANG Huai-li2,ZHUO Zhi-hong2,QIAO Xiao-hui2,CHEN Xiao-xin2(1.Department of Surgery;2.Department of Pediatrics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China);Expression of Matrix Metalloproteinase 9 and Tissue Inhibitor of Metalloprteinase 1 in Rats with Infectious Brain Edema[J];Journal of Applied Clinical Pediatrics;2008-11
7 PAN You-jin,ZHAO Xiang-tong,WU Chao-ming,et al.(Department of Endocrinology,The Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China);THE RELATIONSHIP BETWEEN TYPE 2 DIABETIC MACROANGIOPATHY AND THE LEVELS OF SERUM MATRIX METALLOPROTEINASE 2 AND TISSUE INHIBITOR OF METALLOPROTEINASE 2[J];Modern Preventive Medicine;2007-20
8 MA Da~1,XUE Ke-xiu~1,CAI Xin-hua~2,et al(1.Department of Surgery,the Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453003,China;2.Central Lab of Xinxiang Medical College,Xinxiang 453003,China);Relationship of expression on collagen type Ⅲ and matrix metalloproteinase-1 in Congenital muscular torticollis[J];Journal of Xinxiang Medical College;2007-01
9 YANG Ting-tong,LI Xiu-jie,WU Jun-fang,et al (Department of Pathology Xinxiang Medical College,Xinxiang 453003,China);Influence of the activation of human telomerase reverse transcriptase and the expression of p53 and matrix metalloproteinase-9 on non-small cell lung cancer[J];Journal of Xinxiang Medical College;2007-05
10 LIU Heng-xing1,SHAO Feng2,WANG Huan-zhen1,et al(1.Department of Anatomy,Xinxiang Medical College,Xinxiang 453003,China;2.Department of Orthopaedics,the Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453003,China);Effect of carotene beta on the expression of α-SMA and TGFβ_1 in rats with hepatic fibrosis[J];Journal of Xinxiang Medical College;2008-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 PENG Qian, WU Qing, CHEN Chang-Hui, HONG Hua, ZHANG Ling-Ying. Department of Pediatrics, People's Hospital of Sichuan Province, Chengdu 610072, China;Value of serum soluble interleukin-2R, interleukin-6 and C-reactive protein in the early diagnosis of Kawasaki disease[J];Chinese Journal of Contemporary Pediatrics;2006-03
2 ZHOU Jian,JIANG Hong (Changzhou NO.2 Hospital, affiliated to Nanjing Medical University, Jiangsu Changzhou 213003, China);Changes of platelet parameter and of T lymphocyte subsets in children with Kawasaki disease[J];Journal of Pediatric Pharmacy;2007-04
3 LIAO Ying1,LI Xiang-ling2(1. Maba Hospital of Qujiang;2.Department of Pediatry, The Affiliated Yuebei Hospital of Shantou University Medical College, Shaoguan Guangdong 512000 );Curative effect of intravenous high dose gamma immunoglobulin in 33 children with Kawasaki disease[J];Journal of Gannan Medical University;2008-01
4 Chen Gang,Yu Minghua,Zeng Huasong,et al.Guangzhou Children's Hospital,Guangzhou 510120 China;Change in serum level of soluble E-selectin and MMP-9 in children with Kawasaki disease[J];Guangzhou Medical Journal;2008-02
5 XU Lingmin1),JIA Liting2),DONG Ziming3),HU Sujun1),LUAN Bin1),ZHANG Zhan2)1)Department of Pediatrics,the Third Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Clinical Laboratory,the Third Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 3)Department of Pathophysiology,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001;Determination of plasma soluble P-selectin levels in children with Kawasaki disease and septicemia[J];Journal of Zhengzhou University(Medical Sciences);2008-05
6 HONG Hua, DENG Jun, PENG Qian, et al. Department of Clinical Laboratory,Sichuan Provincial People's Hospital, Chengdu 610072, China;Measurement of serum MMP-9 and TIMP-1 levels in patients with Kawasaki disease[J];Jiangxi Journal of Medical Laboratory Sciences;2005-02
7 WANG Yun,LI Er-zhen,FU Jin,WANG Wei,CUI Xiao-dai,WANG Li,GUO Xing-ping(Department of Pedi-atrics,Children's Hospital Affiliated to Captial Institute of Pediatrics,Beijing 100020,China);Serum interleukin-6 level and its role in coronary artery dilatation in children with Kawasaki disease[J];Journal of Clinical Pediatrics;2007-12
8 ZHENG Dai-ming1,MENG Xiao-Hui2,GAO Zhi-wei1,WANG Jiang-xian1,WANG Yi3,MA Pei-ran3(1.Department of Pediatrics,The People's Hospital of Lishui Affiliated to Wenzhou Medical College,Lishui 323000,Zhejiang,China;2.Department of Diagnosis,School of Medicine,Shandong University,Jinan 250012,Shandong,China;3.Department of Pediatrics,Shandong Provincial Hospital,Jinan 250021,Shandong,China);Analysis of the high risk factors on coronary aneurysms secondary to Kawasaki disease[J];Journal of Clinical Pediatrics;2008-01
9 PIAO Jin-hua1,SUN Jing-hui1,LIU Shi-cheng1,JIN Ying-ji2(1.Department of Cardiology,Jilin University First Hospital,Changchun 130021,Jilin,China;2. Liaoyuan Fetomaternal Hospital,Liaoyuan 136200,Jilin,China);Clinical significance of peripheral blood toxic granulation in Kawasaki disease[J];Journal of Clinical Pediatrics;2008-02
10 XIE Li-jian,XU Meng,HUANG Min,CHEN Xiu-yu,LI Jin-kang,HUA Yang-de(Department of Cardiology,Shanghai Children's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200040,China);547 cases of Kawasaki disease and related risk factors of coronary artery lesion[J];Journal of Clinical Pediatrics;2008-05
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Liu Jingzhang, Zhao Zilin, Gao Yi, et al. Department of Hepatobiliary, Zhujiang Hospital, First Military Medical University, Guangzhou 510282;Study of expression of matrixmetalloproteinases in liver cirrhosis[J];Guangdong Medical Journal;2001-05
2 GAO Hong, HUANG Yao-tian,ZHAO Li,et al.Xinjiang Provincial Crops Hospital,Chinese People's Armed Forces,Wulumuqi 830000,China;The extracellular matrix of the sternocleidomastoid muscle in the congental muscular torticollis: a histochemistry study[J];Modern Rehabilitation;2001-24
3 ZHANG Bin(Department of Infectious Diseases,Changhai Hospital,The Second Military Medical University,Shanghai 200433,China);Research Advance in Pathogenesis of Hepatic Fibrosis[J];Modern Diagnosis & Treatment;2004-06
4 XUE Ke-xiu~1,YAN Hai-yan~2,LIU Tong-Xi~1 (1.The Third Affiliated Hospital of Xinxiang Medical College,Xinxiang,Henan 453003;2.Zhengzhou Children's Hospital,Zhengzhou,Henan 450053);Immunohistochemistry study on collagen type Ⅰand Ⅲ of sternomastoid muscle in congenital muscular torticollis[J];Journal of Xinxiang Medical College;2005-06
5 WANG Jianzhong, CHEN Xiangmei, SHI Suozhu, ZHANG Yanping, TIAN Yue. Division of Nephrology, General Hospital of PLA, Kidney Center and Key Laboratory of PLA, Beijing 100853,China;Expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in IgA nephropathy[J];Chinese Journal of Internal Medicine;2002-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved