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《Journal of Applied Clinical Pediatrics》 2008-02
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Relationship between the Ratio of Plasma Adrenomedullin/Endothelin-1 and Neuron-Specific Enolase in Full-Term Neonates with Hypoxic-Ischemic Encephalopathy

ZHANG Shi-fa,ZHOU Ming-xiong,MAO Shuang-gen,DOU Chang-sheng,XU Guo-cheng(Department of Pediatrics,Yijishan Hospital,Wannan Medical College,Wuhu 241001,China)  
Objective To explore the relationship of the ratio of plasma adrenomedullin(AM)and endothelin-1(ET-1)with serum concentration of neuron-specific enolase(NSE)in full-term neonates with hypoxic-ischemic encephalopathy(HIE).Methods Plasma concentrations of AM,ET-1 and serum NSE from 32 full-term neonates with HIE were detected by radioimmunoassay(RIA)on the 1,3 and 7 d after parturition,30 neonates in the corresponding periods in our hospital were employed as controls.The infants with HIE were divided into mild,moderate or severe group in terms of diagnostic standard of HIE.Results 1.Plasma concentrations of AM and ET-1 in newborns with mild,moderate or severe HIE were significantly higher than that of control group at 1 d after life with a decline from 3-7 d(Pa0.05),and that was significantly higher in the moderate or severe HIE group than that in control group at 7 d(Pa0.05).The ratio of plasma AM and ET-1 in newborns with moderate or severe HIE were significantly lower than that in control group on 1,3 d(Pa0.05).2.Se-rum concentration of NSE in neonates with moderate or severe was markedly higher than that of control group on 1,3 d(Pa0.05).There was also a negative relationship between the ratio of plasma AM/ET-1 and the serum concentration of NSE in neonates with HIE(r=-0.53 P0.05).Conclusions AM can cooperate with ET-1 in the regulation of regional cerebral blood flow and in maintenance of specific blood-brain barrier.Determination of the ratio of plasma AM/ET-1 may demonstrate the flow of regional cerebral blood for evaluating the degree of brain injury.
【CateGory Index】: R722.12
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