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《Journal of Applied Clinical Pediatrics》 2008-11
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Expression of Matrix Metalloproteinase 9 and Tissue Inhibitor of Metalloprteinase 1 in Rats with Infectious Brain Edema

GUO Ai-ling1,TIAN Pei-chao2,WANG Huai-li2,ZHUO Zhi-hong2,QIAO Xiao-hui2,CHEN Xiao-xin2(1.Department of Surgery;2.Department of Pediatrics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)  
Objective To explore the expression and significance of matrix metalloproteinase 9(MMP9) and tissue inhibitor of metalloproteinase 1(TIMP1) in rats with infectious brain edema.Methods Models of acute infectious brain edema of rats were prepared by injected lipopolysaccharide(LPS) via left internal carotid artery,then dry-wet weight method was used to detect the brain water content(BWC).Formamide-method was used to detect Evens blue(EB) content.The expression of MMP9 mRNA and TIMP1 mRNA were examined by reverse transcriptase-polymerase chain reaction(RT-PCR) technique as well as the ratio of MMP9 mRNA and TIMP1 mRNA were analyzed also.Results BWC,EB content and the expression level of MMP9 mRNA and TIMP1 mRNA and the ratio of MMP9 mRNA and TIMP1 mRNA of LPS groups were all higher than that of control groups,there were significant differences(Pa0.05).Meanwhile,BWC and EB content,the expression of MMP9 mRNA and TIMP1 mRNA,the ratio of MMP9 mRNA/TIMP1 mRNA and EB content,the ratio of MMP9 mRNA/TIMP1 mRNA and BWC appeared positive correlations(r=0.455,0.675,0.352,0.396 Pa0.05).Conclusions MMP9 and TIMP1 may be involved in formation and development of infectious brain edema of rats.The imbalance of MMP9 and TIMP1 may play a key roles in the process of infectious brain edema in rats.
【CateGory Index】: R742.9
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