Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Applied Clinical Pediatrics》 2008-14
Add to Favorite Get Latest Update

Changes of Concentrations of Serum Interleukin-18 and Intercellular Adhesion Molecule-1 in Neonates with Hypoxic-Ischemic Encephalopathy

DENG Jin-you1,WEN Yong-zhen1,LI Kai-wen1,HUANG Yu-ge2 (1.Department of Pediatrics,Lianjiang People′s Hospital,Lianjiang 524400,Guangdong Province,China;2.Department of Pediatrics,the Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,Guangdong Province,China)  
Objective To observe changes of serum concentrations of interleukin-18(IL-18) and intercellular adhesion molecule-1(ICAM-1) in neonates with hypoxic-ischemic encephalopathy(HIE) and to explore the correlation of the 2 indices and its effect on patients′condition.Methods Thirty newborn infants met the criteria for HIE.There were 16 cases in mild HIE group,14 cases in moderate and severe HIE group.Twenty normal newborn infants were used as control group.The serum concentrations of IL-18 and ICAM-1 of HIE group and control group were detected using ELISA on the third day and 7th day.Results 1.The IL-18 levels of the mild,moderate and severe HIE and control groups measured within 3 days of life were (120.1±12.7),(175.1±15.4),(100.3±12.5) ng/L,respectively.The concentrations of IL-18 in HIE groups were higher than that of control group(Pa0.05).The concentration of IL-18 in moderate and severe HIE group were higher than that of mild HIE group(P0.05).The concentration on the 7th day was lower than that on the third day(P0.05).2.The ICAM-1 levels of mild,moderate and severe HIE and control groups measured within 3 days of life were (350.45±15.20),(600.10±94.22),(250.12±47.09) μg/L,respectively.The concentrations of ICAM-1 in HIE groups were higher than that of control group(Pa0.05).The concentrations of ICAM-1 in moderate and severe HIE groups were higher than that of mild HIE group(P0.05).The concentration on the 7th day was lower than that on the third day(P0.05).3.The concentration of IL-18 was positively correlated with that of ICAM-1(P0.05).Conclusion Serum IL-18 and ICAM-1 levels can be used as a marker for estimating the severity and the outcome of neonatal HIE.
【Fund】: 湛江市科技攻关项目资助(2006C04014)
【CateGory Index】: R722.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 ZHU Lin-lin1,LIU Cheng-yu2,ZHANG Chen-guang1(1.Department of Laboratory Medicine,Xinxiang Medical College,Xinxiang 453003,China;2.Department of Diagnostics,Qingdao University Medical College,Qingdao 266021,China);Clinical significance of the serum interleukin-18 levels and helicobacter pylori infection in patients with coronary heart disease[J];Journal of Xinxiang Medical College;2009-06
【Citations】
Chinese Journal Full-text Database 3 Hits
1 FANG Yong~1,SUN Yi~2,TANG Cheng-he~2(1.Department of Pediatrics,People′s Hospital of Minquan County,Minquan Henan 476800;2.Department of Pediatrics,the First Affiliated Hospital of Xinxiang Medical College,Weihui Henan 453100);Efficacy of ultra-low-dose heparin as an assisted treatment for neonatal hypoxic-ischmic encephylopathy complicated by systemic inflammatory response syndrome[J];Journal of Xinxiang Medical College;2006-04
2 ZHANG Hui-ling,XU Xian-jun(Department of Paediatrics,the People's Hospital of Neihuang County,Neihuang 456300,China);Lizhusaile combined with massage for treatment of 31 neonatuses with hypoxic-ischemic encephalopathy[J];Journal of Xinxiang Medical College;2007-03
3 ZOU Li-le1,LEI Xiao-ping2,LIU Guang-yi1.(1.Department of Histology and Embryology,Lu Zhou Medical College,Lu Zhou 646000,China; 2.Department of Pediatrics,Affiliated Hospital,Lu Zhou Medical College,Lu Zhou 646000,China);The Relationship Between Interleukin-18 And Hypoxic-Ischemic Brain Damage[J];Medical Recapitulate;2007-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Ai-zhen1,ZHANG Zhen-yu1,ZHANG Yuan-ming1,GUO Xi-rong2,LI Shu-ting2(1.Department of Pediatrics,Taizhou Traditional Chinese Medicine Hospital,Taizhou 225300,China;2.Pediatric Research Institute,Nanjing Medical University,Nanjing 210029,China);Influence of Dexamethasone on Cellular Inhibitor of Apoptosis Protein 1 Gene Expression and Caspase-3 Activity in Brain after Cerebral Hypoxia-Ischemia[J];Journal of Applied Clinical Pediatrics;2007-12
2 WU Hui1,ZHU Gui-bin2,WANG Dong-xuan3(1.Department of Pediatrics,the First Hospital of Jilin University;2.Morphology Experiment Centre,Basic Medical College of Jilin University;3.Department of Ultrasonography,the First Hospital of Jilin University,Changchun 130021,China);Alteration of Apoptosis and Astrocyte in Neonatal Hypoxic-Ischemic Encephalopathy[J];Journal of Applied Clinical Pediatrics;2008-02
3 XU Jian-wen,CHEN Yan-xia;Effect of Large Dose Intravenous Immunolglobuling G Therapy in Neonates with Hypoxic-Ischemic Encephalopalopathy[J];Journal of Applied Clinical Pediatrics;2008-02
4 WANG Jun1,JIANG Hong-xia2,YANG Li-juan1,HE Yan-fang1,ZHOU Chang-mei1,ZHANG Shao-mei1(1.Department of Neonatology,the Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,China;2.Department of Pediatrics,Central Hospital of Xuzhou,Xuzhou 221006,China);Effect of Senmai Injection Therapy on the Level of Serum Interleukin-10,S-100β Protein in Newborn Infants with Hypoxic-Ischemic Encephalopathy[J];Journal of Applied Clinical Pediatrics;2008-02
5 LU Ya-dong,LI Yong,ZHOU Xiao-yu,BEN Xiao-ming(Department of Neonatology,Nanjing Children's Hospital Affiliated to Nanjing Medical University,Nanjing 210008,China);Curative Effects of Monosialotetrahexosyl Ganglioside on Neonates with Moderate and Severe Hypoxic-Ischemic Encephalopathy[J];Journal of Applied Clinical Pediatrics;2008-02
6 CHEN Xiao-wen,CHEN Ke-zheng,LV Hui,TAO Li(Department of Neonatal,Guangzhou Children′s Hospital,Guangzhou 510120,Guangdong Province,China);Comparison between the New and Old Diagnostic Criteria of Neonatal Systemic Inflammatory Response Syndrome in Neonatal Septic Shock[J];Journal of Applied Clinical Pediatrics;2008-13
7 NIU Feng-hai,XU Xin-tan (Department of Pediatrics,the Affiliated Hospital of Jining Medical College,Jining 272029,Shandong Province,China);Influence of Massage on Gastrointestinal Motility of Premature Infants[J];Journal of Applied Clinical Pediatrics;2008-14
8 LIU Ke-yu,ZHANG Zhong-mei,SHEN Yan-hong;Diagnostic Value of Concentration of Plasma N-Terminal Pro-Brain Natriuretic Peptide and Serum Electrolyte Combined Detection in Neonate with Hypoxic-Ischemic Encephalopathy[J];Journal of Applied Clinical Pediatrics;2008-14
9 CHEN Guang-bin1,CHEN Hua-ping1,WU Tie2a,LIN Jian-tao2a,CUI Liao2b,SHEN Fei-chen2c(1.Department of Pharmacy,the Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,Guangdong Province,China;2a.Institute of Traditional Chinese Medicine;2b.Guangdong Key Laboratory for Research and Development of Natural Drugs;2c.Department of Pharmacology,Guangdong Medical College,Zhanjiang 524023,Guangdong Province,China);Effect of Paeoniflorin on Malondlaldehyde and Superoxide Dismutase Levels in Neonatal Rats with Hypoxic-Ischemic Brain Damage[J];Journal of Applied Clinical Pediatrics;2008-16
10 YIN Mei,JIN Yu,GU Jie(Department of Pediatrics,the First Clinical Hospital of Lanzhou University,Lanzhou 730000,Gansu Province,China);Effect of Hypoxia Preconditioning on Change of Neuroglobin in Neonatal Rat with Hypoxia-Ischemia Brain Damage[J];Journal of Applied Clinical Pediatrics;2008-18
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 SUN Ying1,CHEN Yun-feng1,YU Hai-tao2(1.Department of Digestion,Eighth People′s Hospital of Qingdao,Shandong Province,266100,China.2.Municipal Hospital of Qingdao);Relationship between hehcobacter pylori infeetion and the amount of interlenkin-8 and epidemal growth factor in gastric mucosa[J];Chinese Journal of Clinical Healthcare;2008-06
2 LU Hong-zhu1,WU Xiao-hong2,ZHANG Wan-ming1,YUAN Yue-sha1,LIU Dan1(1.Department of Pediatrics,Medical College, Yangtze University;2.Department of Pediatrics, Jingzhou Second Hospital, Jingzhou 434000,China);Significance of Changes of Interleukin-18 Expression Levels of Serum and Peripheral Blood Mononuclear Cells in Children with Steroid-Sensitive Nephrotic Syndrome[J];Journal of Applied Clinical Pediatrics;2007-05
3 YANG Nan,ZHANG Hong-yan,WANG Jing(Department of Cardiology,Tianjin Children's Hospital,Tianjin 300074,China);Study of Serum Interleukin-18,Tumor Necrosis Factor-Alpha,Interferon-Gama Level and Their Relationships in Children with Viral Myocarditis[J];Journal of Applied Clinical Pediatrics;2007-13
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 Wang Shu zhen,Gao Wei wei,Peng Shu mei(Guangdong provincal materal and child health hospital,Guangzhou,China 510010);Evaluation of serum CRP in patients with SIRS[J];PEDIATRIC EMERGENCY MEDICINE;2000-04
2 ZHOU Zhuo-kang, LI Lu-zhe Hangzhou No .3 People's Hospital, Hangzhou 310013, China;Application of heparin in pediatrics[J];Chinese Journal of Biochemical Pharmaceutics;2005-03
3 KANG Wen-qing~1,ZHU Chang-lian~2,XIONG Hong~1,CHENG Xiu-yong~2,WANG Xiao-yang~2(1.Department of Neonatology,Zhengzhou Children′s Hospital,Zhengzhou 450053,China;2.Department of Pediatrics,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China);Neuroprotective Effect of Recombinant Human Erythyropoietin Theraphy for Neonatal Hypoxic-Ischemic Encephalopathy[J];Journal of Applied Clinical Pediatrics;2006-02
4 LIU Wen-bin,WANG Tai-sen,TANG Xue-qing,XU Hong-bo,LIU Hua-jun(Department of Pediatrics,the General Hospital of Chengdu Military Command,Chengdu 610083,China);Study on the Correlation Between Plasma Somatostatin and Cellular Immune Function in Neonates with Hypoxic-Ischemic Encephalopathy[J];Journal of Applied Clinical Pediatrics;2006-02
5 ;Small dosage of dopamine in treatment of 36 newborns with hypoxic ischemic encephalopathy[J];Journal of Xinxiang Medical College;2004-03
6 ZHANG Ling,ZHANG Shu-ling,XUE Ke-xiu,et al (Department of Pediatry,the Third Affiliated Hospital,Xinxiang Medical College,Xinxiang 453003);Study of the protection and safety of magnesium sulfate on hypoxic-ischemicenc ephalopathy of newborns[J];Journal of Xinxiang Medical College;2004-04
7 YANG Cun-ming,SONG Jiany-gang(the First People's Hospital of Dengzhou City,Henan Dengzhou,China 474150);Clinical analysis of 136 newborns with hypoxic-ischemic encephalophy[J];Journal of Xinxiang Medical College;2005-03
8 FANG Yong~1,SUN Yi~2,TANG Cheng-he~2(1.Department of Pediatrics,People′s Hospital of Minquan County,Minquan Henan 476800;2.Department of Pediatrics,the First Affiliated Hospital of Xinxiang Medical College,Weihui Henan 453100);Efficacy of ultra-low-dose heparin as an assisted treatment for neonatal hypoxic-ischmic encephylopathy complicated by systemic inflammatory response syndrome[J];Journal of Xinxiang Medical College;2006-04
9 Li Yong,Zhou Xiaoyu,Xu Zhizhi,et al.Nanjing Children's Hospital Affiliated to Naijing Medical University,Nanjing 210008 Key words Infant,newborn Hypoxic-ischemic encephalopathy Early intervetnion;Effect of early intervention on the prognosis of hypoxic-ischemic encephalopathy in neonates.[J];Chinese Journal of Practical Pediatrics;2000-12
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved