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《Journal of Applied Clinical Pediatrics》 2009-06
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Influence of Single and Multiple Course Dexamethasone on Brain Development of Preterm Infants

CHEN Li-juan,CHENG Xiu-yong(Neonatal Intensive Care Unit,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)  
Objective To explore the effect of single and multiple course dexamethasone on brain development in preterm infants.Met-hods One hundred and eighteen preterm infants delivered after 28-34 weeks′ gestation from Aug.2005 to Mar.2007 in our NICU were enrolled in this study.These infants were divided into 3 groups by antenatalcourses of dexamethasone: control group,single-course group and multi-course group.Supportive treatments were given to all 3 groups.Neonatal behavioral neurological assessment(NBNA) was conducted on expected date of delivery.Mental and psychomotor developmental index was evaluated at 3,6,12 months by using intellectual development table made at Children′s Development Center of China(CDCC).Results The score of NBNA was much higher in single-course group than that in multi-course group and control group(Pa0.05).In 3 and 6 months of corrected age,the scores of mental developmental index(MDI) and psychomotor developmental index(PDI) in single-course group were higher than those in multi-courses group and control group(Pa0.05).At the age of 12 months,the scores of MDI and PDI of multi-course group were lower than those of single-course group and control group(Pa0.05),the scores of single-course group were significantly higher than those of control group(Pa0.05).Conclusions Antenatal single course GCS can improve the short-term and long-term.Exposure to repeated courses of antenatal GCS have bad effect on the short-term prognosis and resulted in more neurodevelopmental abnormalities.
【Fund】: 河南省医学创新人才工程项目资助(2005-62)
【CateGory Index】: R722.1
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