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Clinical Characteristics and Antibiotic Resistance of Staphylococcus Aureus from Skin and Soft Tissue Infections in Children

WANG Qun 1,YANG Yong-hong 2,GENG Wen-jing 2,WU De-jing 2,YUAN Lin 2,YU Sang-jie 2,SHEN Xu-zhuang 2 (1.Department of Pediatrics,the Affiliated Hospital of Guilin Medical College,Guilin 541001,Guangxi Zhuang Autonomous Region,China;2.Laboratory of Microbiology and Immunology,Beijing Children′s Hospital Affiliated to Capital Medical University,Beijing 100045,China)  
Objective To investigate the clinical characteristics and antibiotic resistance of staphylococcus aureus(SAU)from skin and soft tissue infections(SSTIs) in children. Methods A total of 922 children with SSTIs in Beijing children′s hospital from Sep.2008 to Apr.2009 were investigated.The informations of the patients such as sex,age,address,the position of infection,clinical diagnosis,protopathy,the condition of using antibiotics and causative factors were recorded.The SAU strains were isolated from liquor puris,and the strains were identified by using latex agglutination test.The minimal inhibitory concentrations(MIC) of antibiotics against SAU were determined by means of agar dilution method according to the guidelines of the clinical and laboratory standards institute,the data were analyzed by using WHONET 5.4 software. Results Two hundred and ninety-eight strains of SAU were separated and the separation rate was 32.3%,as a result the most common locus were nail groove and omphaloidean.The incidence rate of SSTIs in boys was higher than that in girls,as the rate was 1.87 1.00,and the most common age with SSTIs was 11 d-3 years,which accounted for 57.7%.The most common type of SSTIs was abscess(31.54%),especially abscess from neck(39.4%).The resistance rates of SAU to Penicillin,Erythromycin,Clindamycin,Sulfamethoxazole/Trimethoprim were 85.2%,71.1%,63.7% and 55.6%,respectively,and the MIC 50 and MIC 90 of them were 0.50,256.00,128.00,8.00 and 16,256,256,32,respectively.The resistance rate of SAU to most of the β-lactam antibiotics were below 15%,and the MIC 50 and MIC 90 of them were on the low level.No strain was found to be resistant to vancomycin. Conclusions The incidence rate of SSTIs caused by SAU in boys were higher than that in girls,and young children were the predilection age of onset,in which the most common type was abscess.SAU had strong resistance to Penicillin,Erythromycin,Clindamycin and Sulfamethoxazole/Trimethoprim,but relatively sensitive to most of the β-lactam antibiotics.
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