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Therapeutic Effect of Bergamots Volatile Oil on Asthma

SHI Chang-chun1,WANG Jian-ying1,ZHU Wan-ping2,HUANG Wei-hua2(1.Department of Pediatrics,Jinhua Municipal People′s Hospital,Jinhua 321000,Zhejiang Province,China;2.Zhejiang Provincial Academy of Traditional Chinese Medicine and Pharmacy,Hangzhou 310009,Zhejiang Province,China)  
Objective To explore the effect of bergamots volatile oil on relieving cough,asthma and eliminating phlegm in asthmatic rats and guinea-pig.Methods Bergamot essential oil was extracted by steam distillation,and the experimental guinea-pigs and mice were divi-ded into 3 groups with high,moderate and low doses of bergamot essential oil respectively(1.080,0.540,0.108 g·kg-1for guinea pig,1.753,0.877,0.175 g·kg-1 for mice).The other group were pre-treated with normal saline as model control group,and animals were fed with acute-brochisis-syrup,aminophylline,and xianzhuli oral-liquid as positive drug control groups.After the medication,the guinea pigs were sprayed with citric acid or histamine in a confined glass to induce cough or asthma,while the latent period of cough or asthma attack was detected.The mice were injected phenol red solution through the abdominal cavity,and the tracheal phenol red secretion volume was measured.Results The latent period of cough in high,moderate and low dose of bergamot volatile oil groups and acute-brochisis-syrup group were significantly longer than that of the model control group(Pa0.05,0.01).The latent period of asthma attack in experimental guinea pigs in high,moderate and low dose of bergamots volatile oil groups were all longer than that in model control group(Pa0.05).The phenol red excretion rate in mice-bronchi of the mice pre-treated with bergamot volatile oil were markedly higher than that in model control group(Pa0.05,0.01).Conclusion The bergamot volatile oil is of beneficial to relieving cough,asthma and eliminating phlegm in rats and guinea-pigs with bronchial asthma.
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