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《Journal of Applied Clinical Pediatrics》 2012-12
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Changes of B7-H3 and Interleukin-1β Levels in Cerebrospinal Fluid and Serum in Children with Bacterial Meningitis and It′s Clinical Significance

BAI Yan-hui1,CHEN Xu-qin1,WANG Zhe-dong1,LI Yan1,CUI Wei-li1,ZHANG Guang-bo2,XUE Jian3(1.Department of Neurology,Children′s Hospital Affiliated to Soochow University,Suzhou 215003,Jiangsu Province,China;2.Clinical Immunology Laboratory,Soochow University First Affiliated Hospital,Suzhou 215000,Jiangsu Province,China;3.Clinical Laboratory,Children′s Hospital Affiliated to Soochow University,Suzhou 215003,Jiangsu Province,China)  
Objective To detect the content of soluble costimulatory molecule B7-H3(CD276) and interleukin-1β(IL-1β) in cerebrospinal fluid(CSF) and serum in children with bacterial meningitis(BM) and viral encephalitis(VEM),and to explore their clinical application value. Methods The acute phase of CSF and serum were collected from 17 cases of BM children and 12 cases of VEM children,who were admitted into the Department of Neurology of Children′s Hospital Affiliated to Soochow University from Jul.2010 to Nov.2011.Enzyme linked immunosorbent assay(ELISA) method was adopted to determine the levels of B7-H3 and IL-1β in CSF and serum in BM and VEM.The data were analyzed by using SPSS 17.0 software,and the correlation analysis between the level of B7-H3 and IL-1β was processed. Results The levels of B7-H3 and IL-1β in CSF of BM were significantly higher than those of VEM(P0.01,0.05);The levels of B7-H3 in serum of BM was higher than that of VEM(P0.05).The levels of IL-1β in serum of BM and VEM were not of significant difference(P0.05).The levels of B7-H3 and IL-1β in CSF of BM were positively correlated(r=0.526,P0.05). Conclusions Co-stimulatory molecule B7-H3 levels in CSF and serum can be one of differential diagnosis targets between BM and VEM at their early stage.The levels of B7-H3 and IL-1β in CSF can be one of the early diagnosis indexes of BM.Co-stimulatory molecule B7-H3 and inflammatory factor IL-1β probably take part in the inflammatory process of BM at acute phage.
【Fund】: 国家自然科学基金(30972718)
【CateGory Index】: R725.1
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