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《Journal of Applied Clinical Pediatrics》 2012-15
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Effect of Curcumin on Behavior of Autism Rats and the Expression of Brain Derived Neurotrophic Factor

CHEN Shu-juan,JIANG Zhi-mei,ZHANG Shi-ling,SUN Qi-feng,GUO Lan-min,PANG Wei(Department of Child Development and Behavior,the Third Affiliated Hospital of Jiamusi University,Children Neurological Rehabilitation Lab of Jiamusi University,Jiamusi 154002,Heilongjiang Province,China)  
Objective To study the effect of curcumin on behavior of autism rats and expression of brain derived neurotrophic factor(BDNF).Methods Animal model of autism was established according to Schneider method,the female that received a single intraperitoneal injection of 600 mg·kg-1 sodium valproate on the 12.5 day after conception and then the auxanology,behavioral and morphological test were performed to identify autism mouse.Randomly selected animal model of autism(n=20) and offspring of the NS group(n=10)at age of 35 days,the saline group rats were designated as normal control(Con)group,the animal model of autism was randomly divided into vehicle-control group(VC group,n=10)and curcumin group(VPA-C group,n=10),the VPA-C group was injected curcumin into abdominal for 2 weeks(concentration of curcumin was 10 g·L-1 which was dissolved in PBS containing 1 mL·L-1 dimethyl sulfoxide).The solvent control group and normal control group were given PBS with volume of 1 mL·L-1 DMSO for 2 weeks.This investigation was observed the effects of curcumin on rat behavior and used the immunohistochemical method to observe the expression of BDNF in the different groups.The results were statistically assessed by SPSS 18.0 software.Results The effects of curcumin on autism rats were starting to increase the number of social behavior(P0.05),to decrease latency to social behavior(P0.001),and to reduce repeat behavior of autism mouse(P0.01);Curcumin increased BDNF integral optical density values of autism rats in temporal cortex(P0.05).Conclusions Curcumin have a therapeutic effect on rats with autism,it can be improved abnormal behavior of autism rats to some extent,the mechanism may be to play a role by increasing the expression of BDNF.
【Key Words】: autism brain derived neurotrophic factor sodium valproate curcumin rat
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 JING Jin(Faculty of Maternal and Child Health,School of Public Health,Sun Yat-Sen University,Guangzhou 510080,Guangdong Province,China);Progress in Diagnosis and Treatment for Children with Autistic Spectrum Disorders[J];Journal of Applied Clinical Pediatrics;2010-23
2 LEI Jun-rong,QIN Jun,ZHANG Jing,HUANG Kuan-ming,FU Rui,ZHOU Zhang-ming (Taihe Hospital,Yunyang Medical College,Shiyan Hubei 442000,China);Effects of curcumin on inflammatory reaction and blood-brain barrier permeability in rats following cerebral ischemic injury[J];Chinese Pharmacological Bulletin;2010-01
3 CHEN Shu-juan, JIANG Zhi-mei, GUO Lan-min, et al. Department of Child Development and Behavior, the Third Affiliated Hospital, Children Neurological Rehabilitation Lab, Jiamusi University, Jiamusi 154003, Heilongjiang, China;Expression of Brain-derived Neurotrophic Factor in Temporal Cortex of Autism Model Rats[J];Chinese Journal of Rehabilitation Theory and Practice;2012-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Gang,GU Tian,ZHOU Yun.Guilin Medical College,Guilin 541001,China;The relationship between symptom severity and blood levels of serum microelements among children with autistic disorders[J];Journal of Clinical Psychiatry;2012-04
2 JIAO Yun, LIU Fei, LIU Li-yan, CAI Xiao-fan. People's Hospital of Hainan Province. Haikou570311,Hainan Province,CHINA;Clinical efficacy of risperidone in 11 children with autism spectrum disorders[J];Hainan Medical Journal;2013-04
3 Pang Chunhong,Li Pengtao,Zhu Xiaolei (Pathology Department,Sino-Japan Friendship Hospital,Add.:No.2 Yinghua East road,Chaoyang District,Beijing,Post code:100029);Impairment Mechanism of TNF-α in Ischemia-reperfusion Rats and Effect of Qingkailing[J];World Chinese Medicine;2011-04
4 YU Rong-rong,XU Yun,XU Dan,LIN Liang-hua(Department of Psychology,School of Educational Science and Technology,Zhejiang University of Technology,Hangzhou 310014,Zhejiang Province,China);Theory of Mind in Children with Autism and Its Application in Intervention[J];Journal of Applied Clinical Pediatrics;2012-06
5 TAO Lu-ling1,LIU Ke2(1.Henan Traditional Chinese Medicine College,Zhengzhou 450003,China;2.First Affiliated Hospital of Henan Traditional Chinese Medical College,Zhengzhou 450003,China);Experimental Research Progress on Chinese Medicine Monome Protection of Cerebral Ischemia Reperfusion Injury[J];Lishizhen Medicine and Materia Medica Research;2012-12
6 YUN Tian-tian~1,WANG Hua-ting~2,WANG Shu-mei~2,SU Guo-hai~2,LI Chang-ling~2 (1.School of Medicine,Shandong University;2.Dept of Cardiology,Jinan Central Hospital Affiliated to Shandong University,Jinan 250013,China);Protective effects of sindacon on myocardial ischemic reperfusion injury in rats[J];Chinese Pharmacological Bulletin;2010-07
7 SUN Ya-xuan1,2,LIU Ting3,DAI Xue-ling1,GAO Zhao-lan1,WEI Rong1,ZHENG Qiu-sheng3,JIANG Zhao-feng1 1.College of Arts and Sciences,Beijing Union University,Beijing 100191,China;2.Cold and Arid Regions Environmental and Engineering Research Insitute,Chinese Academy of Sciences,Lanzhou 730000,China;3.School of Pharmacy,Shihezi University,Shihezi Xinjiang 832003,China);A study of the effect of chitooligosaccharides on cerebral ischemia/reperfusion in mice[J];Chinese Pharmacological Bulletin;2010-09
8 NIE Qin 1,XIN Xian-liang1,2,GENG Mei-yu1,2(1.Molecular Pharmacology Laboratory,Department of Pharmacology,Ocean University of China,Qingdao Shandong 266003,China;2.Division of Anti-tumor Pharmacology,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China);Advances in research of glucose transporter-1[J];Chinese Pharmacological Bulletin;2010-10
9 LI Xin-juan,LI Shuang,Li Dong-liang(Dept of Physiology and Neurobiology,Xinxiang Medical University,Xinxiang Henan 453003,China);Effects of progesterone on blood brain barrier permeability and brain edema following hypoxic-ischemic brain damage in newborn rats[J];Chinese Pharmacological Bulletin;2011-03
10 JI Feng-tao1,2,CAO Ming-hui1,2,LIANG Jian-jun2,LIU Ling2,LI Feng1,BU Xian-zhang3(1.Dept of Anatomy and Neurobiology,Zhongshan School of Medicine,Sun Yat-Sen University,Guangzhou 510080,China; 2.Dept of Anesthesiology,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,China; 3.School of Pharmaceutical Sciences,Sun Yat-Sen University,Guangzhou 510006,China);Effects of chemical synthesized curcumin preconditioning on the expression of AQP-4 and cerebral edema after focal cerebral ischemia/reperfusion damage in rats[J];Chinese Pharmacological Bulletin;2011-04
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 XUN Guang-lei1,HE Yi-qun2,ZHAO Jing-ping1 (1.Mental Health Institute,the Second Xiangya Hospital of Central South University,Changsha 410011,China;2.The First Department of Psychophysiological Disorder,the Second Affiliated Hospital of Xinxiang Medical College,Xinxiang 453002,China);Control study on plasma levels of glutamic acid and gamma-aminobutyric acid in childhood autism of Han nucleus family[J];Journal of Xinxiang Medical College;2010-02
2 OUYANG Chang-Han, WU Ji-Liang, HE Zhen-Hua, SHI Zhen-Jiao (Dept of Pharmacology, Xianning College,Xianning Hubei 437100, China);Protective effect of rosiglitazone on cerebral ischemia/reperfusion injury in rats[J];Chinese Pharmacological Bulletin;2007-01
3 ZHOU Rui1, XU Chun-hong2, LI Jun1, CAO Hong1(1. Dept of Anesthesiology, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou Zhejiang 325027, China; 2. Dept ofAnesthesiology, The Affiliated Sir Run Run Shaw Hospital of Medical College of Zhejiang University,Hangzhou 310016,China);Effects of curcumin on the expressions of NR2A,NR2B and apoptotic neurons in hippocampus after ischemia-reperfusion in rats[J];Chinese Pharmacological Bulletin;2008-10
4 ;孤独症神经心理特征和相关脑机制[J];Chinese Journal of Practical Pediatrics;2008-03
5 ;应重视和加强高功能广泛性发育障碍的诊疗工作[J];Chinese Journal of Practical Pediatrics;2009-06
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