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《Chinese Journal of General Practice》 2011-07
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Inhibitory Effect of Quercetin on Invasion of Colon Cancer Cell SW480

MENG Yong,LI Hua,LIN Zeng-hai,et al.Department of General Surgery,the First Affiliated Hospital of Medical School of Shantou University,Shantou 515041,Guangdong,China  
Objective To investigate the appearance and structure changes of SW 480 after treated by quercetin,and to explore the effects of Quercetin on invasion,metastasis and adhesion in human SW480 cell.Methods The morphological changers of SW480 were investigated by microscopically and electro microscopically examination.The effect of different concentrations of Quercetin on SW480 cell for 24,48,72 hour was observed;Matrigel Basement Membrane Matrix was used to investigate the effects of Quercetin on invasion,metastasis and adhesion in human SW480 cell.Results Light microscopic observation showed that the amount of SW480 cells decreased,partial cells volume shrunk,the morphology of SW480 was irregular,cytoplasmic condensation,vacant bubbles,condensed nuclei and condensed chromatin after treated with Quercetin.Under electron microscope,SW480 cell exhibited that endoplasmic reticulum swollen,ribosome decreased,cytoplasmic condensation,pyknotic nuclei and apoptotic bodies;The amount of human colon carcinoma cell line SW480 treated by Quercetin decreased with dose and time dependent.After treated by Quercetin,the ability of invasion,metastasis and adhesion descended with dose and time dependent.Conclusion Quercetin can inhibit the growth of human colon carcinoma cell line SW480 by inhibiting the ability of invasion,metastasis and adhesion and induce cell apoptosis.Many key points in the invasive and metastasis process were enrolled in.
【Fund】: 2009年广东省中医药局科研课题(2009232);; 2009年广东省科技攻关项目(2009B030801321)
【CateGory Index】: R735.35
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