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《Chinese Journal of General Practice》 2011-10
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Combined Detection of Serum Cystatin-C and Urinary Bata 2 Microglobulin in Patients with Early Diabetic Nephropathy

JIANG Peng,LIANG Ming.Department of Nephrology,Dongying People's Hospital,Dongying,Shangdong 257091,China  
Objective To investigate the diagnostic value of combined detection of serum Cystatin-C and urinary Bata 2 microglobulin in patients with type 2 diabetic nephropathy.Methods According to microalbuminuria level,62 patients who were diagnosed type 2 diabetes were divided into three groups,the serum Cystatin-C and urinary Bata 2 microglobulin were examined by using immune nephelometry and reaction rate assay.The concentration and positive rate were compared with the control.Results The level of serum Cystatin-C and urinary Bata 2 microglobulin in type 2 diabetic patients were significantly higher than those of the control(P0.01);The positive rate of serum Cystatin-C test,urinary Bata 2 microglobulin test and combined test was 41.67%,36.67% and 65.00%,respectively,and the difference were significant(P0.01).Conclusion The serum Cystatin-C and urinary bata2 microglobulin may be sensitive and reliable marker for predicting the early damage in type 2 diabetic patients;the combined detection with serum Cystatin-C and urinary Bata 2 microglobulin is important for the early diagnosis of diabetic nephropathy.
【CateGory Index】: R587.24
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