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《Chinese Journal of General Practice》 2012-08
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The Effects of Ginkgo Biloba Extract on Inflammatory Response and Oxidative Stress in ARDS

WU Xiao-qin,HUANG Zhao,WANG Si-rong,et al.ICU,First Municipal People's Hospital of Guangzhou,Guangzhou 510180,Guangdong,China  
Objective To investigate the effects of Ginkgo biloba extract(EGb) on inflammatory response and oxidative stress in acute respiratory distress syndrome(ARDS).Methods Sixty-two patients suffering from ARDS were randomly divided into two groups.The control group was treated regularly and the treatment group was added EGb injection.The plasma maleic dialdehyde(MDA),glutathione(GSH),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) of all patients were monitored and analyzed before and after treatment.Results All patients in treatment group were improved in the indexes of MDA,GSH,SOD,GSH-Px,TNF-α,IL-6 in plasma level when compared with the control one(all P0.05).It was found that plasma TNF-α,IL-6 were negatively correlated(P0.05) with GSH,GSH-Px,SOD and was positively correlated with MDA(P0.05).More higher level of TNF-α,IL-6,MDA and lower GSH,GSH-Px,SOD in dead patients(P0.05).Conclusion EGb can not only inhibit inflammatory mediator but also effective plasma eliminate free radicals in ARDS.It maybe has benefit effect on the treatment of ARDS patients.
【Fund】: 广东省中医药管理局科研基金资助(2007228)
【CateGory Index】: R563.8
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