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《Chinese Journal of General Practice》 2013-02
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Effects of Edaravone on Pulmonary Function during One-lung Ventilation in Elderly Patients

ZHANG Jun,HE Wen-sheng,HU Yuan,et al.Department of Anesthesiology,the Second People's Hospital of Hefei,Hefei 230009,Anhui,China  
Objective To investigate the effects of edaravone on the lung function during one lung ventilation in elder patients.Methods Forty ASAⅠ or Ⅱ patients undergoing elective esophageal cancer resection,aged 60-75 years,BMI 18~26 kg/m2,were randomly divided into 2 groups(n=20 each): control group(group C) and edaravone group(group E).In the group E,edaravone was infused before anesthesia at 60.0 mg/h for 30 min.Then the infusion rate was reduced to 7.5 mg/h and maintained until the end of operation.In the group C,equal volume of normal saline was infused instead of edaravone.MAP,HR,CVP,mean airway pressure were monitored and recorded at before OLV(T0),at 60 min of OLV(T1) and 30 min after re-expansion of the collapsed lung(T2).Blood samples were taken simultaneously from jugular vein and radial artery for blood gas analysis and respiratory index(RI)(RI=PA-aO2/PaO2) were calculated.Results There was no significant difference in mean airway pressure,PaO2 and RI before one lung ventilation between the two groups(T0).Compared with T0,the values of PaO2 were lower and mean airway pressure and RI were significantly increased in the two groups at T1-2(P0.05).The values of PaO2 in group E is higher and mean airway pressure and RI is lower than that in group C at T1-2(P0.05).Conclusion Edaravone can reduce the lung injury during one lung ventilation and provide better lung protection in elder patients.
【CateGory Index】: R735.1
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