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《Journal of Shenyang Sport University》 2011-01
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Effect of Overtraining on Free Radical Metabolism and Activity of PKB in Rat Skeletal Muscle

LI Linyan (P.E.Department,Jingdezhen Ceramic Institute,Jingdezhen 333001,Jiangxi,China)  
Objective:to investigate the mechanism of overtraining and observe the influence to p38 MAPK on free radical Metabolism of skeletal muscle caused by overtraining for six weeks.Methods:thirty male SD rats were randomly divided into control group without training and overtraining group.The rats in the overtraining groups took incremental over training for 6 weeks;Fatigue was evaluated by overall functional status and conventional biochemical indicators.In the further determination,the MDA,SOD,total antioxidant capacity and the protein expression of p38 were determined.Results:serum cortisol,Testosterone/Corticosterone,Hb of the rats in overtraining group decreased significantly(P0.01),BUN increased significantly(P0.01).Serum cortisol,Testosterone/Corticosterone,Hb in overtraining group is decreased by 71.81%,85.21% and 23.12% respectively.Corticosterone in overtraining group is 94.79% higher than that in the control group.They overtook reference standard for diagnosis of human over-training for 30%,30%,20%,20%.Each MDA in skeletal muscle increased significantly(P0.01),SOD and simultaneously total antioxidant capacity in skeletal muscle decreased significantly(P0.05),simultaneously.Muscle glycogen content did not change significantly,glucose decreased significantly,and the protein expression of p38 increased significantly(P0.01).Conclusion:large amount of energy consumption in skeletal muscle,the increasing of radical generation,the reduced antioxidant capacity,excess radical caused by overtraining activated MAPK,but didn't increase the content of muscle glycogen.It is speculated that MAPK regulates skeletal muscle metabolic may be inhibited by the low glucose.
【CateGory Index】: G804.7
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