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《Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease》 2004-05
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The effects of puerarin on left ventricular hypertrophy in essential hypertensive patients

Jiang Zhip-ing, Xiao Lizhong, Xu Xin ,et al. Yuebei Hospital, Shaoguan Guangdong ,512026  
Objective To investigate the effects of puerarin on left ventricular hypertrophy in essential hypertensive pa-tients and possible mechanism. Methods 58 essential hypertensive patients with left ventricular hypertrophy were randomly di-vided into control group(n = 28) and puerarin group(n = 30) ,they treated with antihypertensive drug Luobuma and hydrochlorothi-azide,on the basis of therapy puerarin group added puerarin 195mg/d for 6 months.The left ventricular mass index(LVMI) ,nitric oxide(NO),endothelin-1(ET-1) and free fatty acids(FFA) were examined and estimated before and after treatment. Results In puerarin group LVMI,FFA and ET-1 decreased,NO increased( P 0.01),the change of LVMI was positively conelated with the change of ET-1 and FFA( r = 0.44,0.41, P 0.05), negatively with NO( r = -0.37, P 0.05), No significant change was found in control group( P 0.05). Condusion The treatment of puerarin showed that it could effectively reverse the left ventricular hypertrophy,and the therapeutic mechanism might be improvement of endothelial function and fatty acids metabolism.
【CateGory Index】: R541.3
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